Perfluorocarbon-Loaded Lipid Nanocapsules to Assess the Dependence of U87-Human Glioblastoma Tumor pO.sub.2 on In Vitro Expansion Conditions

Growing tumor cell lines, such as U87-MG glioma cells, under mild hypoxia (3% O.sub.2) leads to a ca. 40% reduction in growth rate once implanted in the brain of nude mice, as compared to normoxia (21% O.sub.2) grown cells, wherein the former over-express HIF-1 and VEGF-A. Despite developing differe...

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Veröffentlicht in:	PloS one 2016-10, Vol.11 (10), p.e0165479
Hauptverfasser:	Lemaire, Laurent, Nel, Janske, Franconi, Florence, Bastiat, Guillaume, Saulnier, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Development and progression Gliomas Perfluorocarbons Vascular endothelial growth factor
Online-Zugang:	Volltext
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