Clinical dose of lidocaine destroys the cell membrane and induces both necrosis and apoptosis in an identified Lymnaea neuron

Purpose Although lidocaine-induced cell toxicity has been reported, its mechanism is unclear. Cell size, morphological change, and membrane resistance are related to homeostasis and damage to the cell membrane; however, the effects of lidocaine on these factors are unclear. Using an identified LPeD1...

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Veröffentlicht in:	Journal of anesthesia 2012-02, Vol.26 (1), p.54-61
Hauptverfasser:	Onizuka, Shin, Tamura, Ryuji, Yonaha, Tetsu, Oda, Nobuko, Kawasaki, Yuko, Shirasaka, Tetsuro, Shiraishi, Seiji, Tsuneyoshi, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Anesthetics, Local - toxicity Animals Annexin A5 - analysis Apoptosis Apoptosis - drug effects Cell Membrane - drug effects Cell Membrane - pathology Cell membranes Critical Care Medicine Electric Capacitance Emergency Medicine Intensive Lidocaine Lidocaine - toxicity Lymnaea Medicine Medicine & Public Health Membrane lipids Membrane Potentials - drug effects Necrosis Neurons Neurons - drug effects Neurons - pathology Neurons - physiology Nucleic acids Original Article Pain Medicine
Online-Zugang:	Volltext
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