Expression of importin-[alpha] isoforms in human nasal mucosa: implication for adaptation of avian influenza A viruses to human host
Transportation into the host cell nucleus is crucial for replication and transcription of influenza virus. The classical nuclear import is regulated by specific cellular factor, importin-[alpha]. Seven isoforms of importin-[alpha] have been identified in human. The preference of importin-[alpha]3 of...
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| Veröffentlicht in: | Virology journal 2016-06, Vol.13 (1) |
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| creator | Ninpan, Khwansiri Suptawiwat, Ornpreya Boonarkart, Chompunuch Phuangphung, Peerayuht Sathirareuangchai, Sakda Uiprasertkul, Mongkol Auewarakul, Prasert |
| description | Transportation into the host cell nucleus is crucial for replication and transcription of influenza virus. The classical nuclear import is regulated by specific cellular factor, importin-[alpha]. Seven isoforms of importin-[alpha] have been identified in human. The preference of importin-[alpha]3 of avian influenza virus and -[alpha]7 isoform of human strains during replication in human cells was previously identified. In addition, both avian and human influenza viruses were shown to use importin-[alpha]1 isoform for their replication. These results may explain the preference of importin-[alpha]7 isoforms in seasonal influenza viruses in human upper respiratory tract and may suggest a selective pressure toward importin-[alpha]7 in human respiratory tract infection of an avian virus. |
| doi_str_mv | 10.1186/s12985-016-0546-y |
| format | Article |
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| ispartof | Virology journal, 2016-06, Vol.13 (1) |
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| language | eng |
| recordid | cdi_gale_infotracmisc_A463818629 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Avian influenza Care and treatment Physiological aspects |
| title | Expression of importin-[alpha] isoforms in human nasal mucosa: implication for adaptation of avian influenza A viruses to human host |
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