Spontaneous tumor development in bone marrow-rescued DNA-[PKcs.sup.3A/3A] mice due to dysfunction of telomere leading strand deprotection

Phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) at the Thr2609 cluster is essential for its complete function in DNA repair and tissue stem cell homeostasis. This phenomenon is demonstrated by congenital bone marrow failure occurring in DNA-[PKcs.sup.3A/3A] mutant mi...

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Veröffentlicht in:	Oncogene 2016-07, p.3909
Hauptverfasser:	Zhang, S, Matsunaga, S, Lin, Y.-F, Sishc, B, Shang, Z, Sui, J, Shih, H.-Y, Zhao, Y, Foreman, O, Story, M.D, Chen, D.J, Chen, B.P.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis DNA repair Gene mutations Genetic aspects Health aspects Properties Telomeres
Online-Zugang:	Volltext
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