Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G[α.sub.13]/RhoA axis in B cells

G proteins and their cognate G protein-coupled receptors (GPCRs) function as critical signal transduction molecules that regulate cell survival, proliferation, motility and differentiation. The aberrant expression and/or function of these molecules have been linked to the growth, progression and met...

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Veröffentlicht in:	Oncogene 2016-07, Vol.35 (29), p.3771
Hauptverfasser:	O'Hayre, M, Inoue, A, Kufareva, I, Wang, Z, Mikelis, C.M, Drummond, R.A, Avino, S, Finkel, K, Kalim, K.W, DiPasquale, G, Guo, F, Aoki, J, Zheng, Y, Lionakis, M.S, Molinolo, A.A, Gutkind, J.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Burkitt's lymphoma Care and treatment Development and progression G proteins Gene expression Genetic aspects Health aspects Identification and classification Properties Tumor suppressor genes
Online-Zugang:	Volltext
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