Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP-PKG-K.sub.ATPChannel Signaling Pathway

In the present study, the effect and mechanism of action of the flavonoid naringenin were evaluated in superoxide anion donor (KO.sub.2 )-induced inflammatory pain in mice. Naringenin reduced KO.sub.2 -induced overt-pain like behavior, mechanical hyperalgesia, and thermal hyperalgesia. The analgesic...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4)
Hauptverfasser:	Manchope, Marília F, Calixto-Campos, Cássia, Coelho-Silva, Letícia, Zarpelon, Ana C, Pinho-Ribeiro, Felipe A, Georgetti, Sandra R, Baracat, Marcela M, Casagrande, Rúbia, Verri, Waldiceu A
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Cellular signal transduction Flavonoids Health aspects Pain
Online-Zugang:	Volltext
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