A promoter SNP rs4073TA in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

Background Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased in the lung with IPF. We evaluated the effect of single nucleotide polymorphisms (SNPs)...

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Veröffentlicht in:	Respiratory research 2011-06, Vol.12 (78), p.73
Hauptverfasser:	Ahn, Mi-Hyun, Park, Byung-Lae, Lee, Shin-Hwa, Park, Sung-Woo, Park, Jong-Sook, Kim, Do-Jin, Jang, An-Soo, Park, Jai-Soung, Shin, Hwa-Kyun, Uh, Soo-Taek, Kim, Yang-Ki, Kim, Young Whan, Han, Sung Koo, Jung, Ki-Suck, Lee, Kye Young, Jeong, Sung Hwan, Park, Jeong Woong, Choi, Byoung Whui, Park, In Won, Chung, Man Pyo, Shin, Hyoung Doo, Song, Jin Woo, Kim, Dong Soon, Park, Choon-Sik, Shim, Young-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allelomorphism Analysis Cancer Chemotherapy Development and progression Enzymes Genes Genetic aspects Health aspects Interleukin-8 Interleukins Promoters (Genetics) Pulmonary fibrosis Respiratory tract diseases Risk factors RNA Single nucleotide polymorphisms
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