Radiocomplexation and evaluation of the .sup.99mTc-Gemifloxacin in artificially Escherichia coli infected mice

Radiocomplexation and evaluation of the .sup.99mTc-Gemifloxacin in artificially Escherichia coli infected mice

Gemifloxacin as a broad spectrum quinolone antibacterial agent was radiocomplexed with high activity of .sup.99mTc and was evaluated as an infection imaging agent in artificially Escherichia coli (E. Coli) infected mice. .sup.99mTc-Gemifloxacin with high specific activity (0.148 GBq/μmol) and labeli...

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Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2016-06, Vol.308 (3), p.825
Hauptverfasser: Erfani, M, Rekabgardan, M, Mortazavi, P, Shafiei, M
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Sprache:eng
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Bacteria
Bacterial pneumonia
Health aspects
Pneumonia
Radiation
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creator Erfani, M
Rekabgardan, M
Mortazavi, P
Shafiei, M
description Gemifloxacin as a broad spectrum quinolone antibacterial agent was radiocomplexed with high activity of .sup.99mTc and was evaluated as an infection imaging agent in artificially Escherichia coli (E. Coli) infected mice. .sup.99mTc-Gemifloxacin with high specific activity (0.148 GBq/μmol) and labeling yield (98.60 ± 0.70 %) was obtained. Our main achievement was high accumulation in the E. Coli infected right thigh muscle in mice (T/NT = 1.89 at 4 h post injection) which may diagnostically be beneficial to distinguish sites of E. Coli infection.
doi_str_mv 10.1007/s10967-015-4515-5
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subjects Bacteria
Bacterial pneumonia
Health aspects
Pneumonia
Radiation
title Radiocomplexation and evaluation of the .sup.99mTc-Gemifloxacin in artificially Escherichia coli infected mice
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