induced senescence of pancreatic beta cells enhances insulin secretion

Cellular senescence is thought to contribute to age-associated deterioration of tissue physiology. The senescence Effector [p16.sup.Ink4a] is expressed in pancreatic beta cells during aging and limits their proliferative potential; however, its effects on beta cell function are poorly characterized....

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Veröffentlicht in:	Nature medicine 2016-04, p.412
Hauptverfasser:	Helman, Aharon, Klochendler, Agnes, Azazmeh, Narmen, Gabai, Yael, Horwitz, Elad, Anzi, Shira, Swisa, Avital, Condiotti, Reba, Granit, Roy Z, Nevo, Yuval, Fixler, Yaakov, Shreibman, Dorin, Zamir, Amit, Tornovsky-Babeay, Sharona, Dai, Chunhua, Glaser, Benjamin, Powers, Alvin C, Shapiro, A.M. James, Magnuson, Mark A, Dor, Yuval, Ben-Porath, Ittai
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Cell proliferation Cells Genetic aspects Health aspects Insulin Pancreatic beta cells Properties
Online-Zugang:	Volltext
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