MicroRNA-155 controls affinity-based selection by protecting [c-MYC.sup.+] B cells from apoptosis

The production of high-affinity antibodies by B cells is essential for pathogen clearance. Antibody affinity for antigen is increased through the affinity maturation in germinal centers (GCs). This is an iterative process in which B cells cycle between proliferation coupled with the acquisition of m...

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Veröffentlicht in:	The Journal of clinical investigation 2016-01, p.377
Hauptverfasser:	Nakagawa, Rinako, Leyland, Rebecca, Meyer-Hermann, Michael, Lu, Dong, Turner, Martin, Arbore, Giuseppina, Phan, Tri Giang, Brink, Robert, Vigorito, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis MicroRNA
Online-Zugang:	Volltext
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