Strong Expression of Hypoxia-Inducible Factor-1[alpha] (HIF-1[alpha]) Is Associated with Axl Expression and Features of Aggressive Tumors in African Breast Cancer

Inhibition of hypoxia-inducible factor (HIF) and Axl receptor tyrosine kinase is being evaluated for targeted therapy in solid tumors. Both HIF-1[alpha] and Axl influence tumor growth and metastatic potential, and they have been linked to treatment failure in many cancers. However, there is a lack o...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1)
Hauptverfasser:	Nalwoga, Hawa, Ahmed, Lavina, Arnes, Jarle B, Wabinga, Henry, Akslen, Lars A
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast tumors Development and progression Health aspects Phosphotransferases Transcription factors
Online-Zugang:	Volltext
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