A One-Pot and Efficient Synthesis of Zoledronic Acid Starting from Tert-butyl Imidazol-1-yl Acetate

A one-pot synthesis of zoledronic acid in high yield is described. The procedure involves a non-aqueous ester cleavage of the tert -butyl imidazol-1-yl acetate under dry conditions in the presence of methanesulfonic acid as solubilizer and chlorobenzene as solvent to afford in situ the corresponding...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2015-03, Vol.48 (12), p.835-839
Hauptverfasser:	Ratrout, Samer S., Al Sarabi, Ala’eddine M., Sweidan, Kamal A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Bone disorder agents Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Phosphates Phosphoric acid Telomerase
Online-Zugang:	Volltext
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