p31.sup.comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2

Mad2, a key component of the spindle checkpoint, is closely associated with chromosomal instability and poor prognosis in cancer. p31.sup.comet is a Mad2-interacting protein that serves as a spindle checkpoint silencer at mitosis. In this study, we showed that p31.sup.comet -induced apoptosis and se...

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Veröffentlicht in:	PloS one 2015-11, Vol.10 (11)
Hauptverfasser:	Shin, Hyun-Jin, Park, Eun-Ran, Yun, Sun-Hee, Kim, Su-Hyeon, Jung, Won-Hee, Woo, Seon Rang, Joo, Hyun-Yoo, Jang, Su Hwa, Chung, Hee Yong, Hong, Sung Hee, Cho, Myung-Haing, Park, Joong-Jean, Yun, Miyong, Lee, Kee-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Chemical properties Gene mutation Genetic aspects Physiological aspects Tumor proteins
Online-Zugang:	Volltext
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