Inhibition of Zn

Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement. Many antibacterial and anticancer drugs act as topoisome...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3)
Hauptverfasser:	Cheng, Bokun, Annamalai, Thirunavukkarasu, Sandhaus, Shayna, Bansod, Priyanka, Tse-Dinh, Yuk-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological products Cysteine Enzymes Fluorescence Topoisomerase I
Online-Zugang:	Volltext
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