Sequential Application of Ligand and Structure Based Modeling Approaches to Index Chemicals for Their hH.sub.4R Antagonism

The human histamine H.sub.4 receptor (hH.sub.4 R), a member of the G-protein coupled receptors (GPCR) family, is an increasingly attractive drug target. It plays a key role in many cell pathways and many hH.sub.4 R ligands are studied for the treatment of several inflammatory, allergic and autoimmun...

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Veröffentlicht in:	PloS one 2014-10, Vol.9 (10)
Hauptverfasser:	Pappalardo, Matteo, Shachaf, Nir, Basile, Livia, Milardi, Danilo, Zeidan, Mouhammed, Raiyn, Jamal, Guccione, Salvatore, Rayan, Anwar
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical properties Histamine
Online-Zugang:	Volltext
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