Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells

Rapidly cycling fetal and neonatal hematopoietic stem cells (HSCs) generate a pool of quiescent adult HSCs after establishing hematopoiesis in the bone marrow. We report an essential role for the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition. Emergen...

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Veröffentlicht in:	The Journal of clinical investigation 2015-05, Vol.125 (5)
Hauptverfasser:	Jones, Morgan, Chase, Jennifer, Brinkmeier, Michelle, Xu, Jing, Weinberg, Daniel N, Schira, Julien, Friedman, Ann, Malek, Sami, Grembecka, Jolanta, Cierpicki, Tomasz, Dou, Yali, Camper, Sally A, Maillard, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Genes Genetic aspects Hematopoietic stem cells Physiological aspects
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