methylguanine-DNA methyltransferase as a prognostic and predictive marker for basal-like breast cancer treated with cyclophosphamide-based chemotherapy

The [O.sup.6]-methylguanine-DNA methyltransferase (MGMT) protein protects cells from alkylating agents by removing alkyl groups from the [O.sup.6]-position of guanine. However, its effect on DNA damage induced by cyclophosphamide (CPM) is unclear. The present study investigated whether MGMT expressi...

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Veröffentlicht in:	Oncology letters 2014-06, Vol.7 (6), p.1778
Hauptverfasser:	Isono, Sayuri, Fujishima, Makoto, Azumi, Tatsuya, Hashimoto, Yukihiko, Komoike, Yoshifumi, Yukawa, Masao, Watatani, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cyclophosphamide Dosage and administration Genetic aspects Methyltransferases Prognosis Properties
Online-Zugang:	Volltext
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