Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments

Synthesis and Study of 1,3- and 1,3,3-Substituted Ureas Containing Isoxazole and Adamantane Fragments

A series of 1,3-disubstituted and 1,3,3-trisubstituted isoxazolyl- and adamantyl-functionalized ureas was synthesized. The resulting compounds are potent inhibitors of soluble epoxide hydrolase. The compounds were obtained in high yields under mild conditions. Water solubility of the synthesized ure...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2015-03, Vol.50 (12), p.1719-1726
Hauptverfasser: Butov, G. M., Burmistrov, V. V., Dalinger, I. L., Vatsadze, I. A., Shkineva, T. K., Danilov, D. V.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics
Chemistry
Chemistry and Materials Science
Fatty acids
Hydrolases
Isocyanates
Organic Chemistry
Pharmacy
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Zusammenfassung:A series of 1,3-disubstituted and 1,3,3-trisubstituted isoxazolyl- and adamantyl-functionalized ureas was synthesized. The resulting compounds are potent inhibitors of soluble epoxide hydrolase. The compounds were obtained in high yields under mild conditions. Water solubility of the synthesized ureas was found to exceed significantly that of known analogs.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-015-1643-3