Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3

Familial hyperkalemic hypertension (FHHt) is a monogenic disease resulting from mutations in genes encoding WNK kinases, the ubiquitin scaffold protein cullin 3 (CUL3), or the substrate adaptor kelch-like 3 (KLHL3). Disease-associated CUL3 mutations abrogate WNK kinase degradation in cells, but it i...

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Veröffentlicht in:	The Journal of clinical investigation 2014-11, Vol.124 (11), p.4723
Hauptverfasser:	McCormick, James A, Yang, Chao-Ling, Zhang, Chong, Davidge, Brittney, Blankenstein, Katharina I, Terker, Andrew S, Yarbrough, Bethzaida, Meermeier, Nicholas P, Park, Hae J, McCully, Belinda, West, Mark, Borschewski, Aljona, Himmerkus, Nina, Bleich, Markus, Bachmann, Sebastian, Mutig, Kerim, Argaiz, Eduardo R, Gamba, Gerardo, Singer, Jeffrey D, Ellison, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene mutations Genetic aspects Health aspects Hypertension Kidney diseases Phosphotransferases Physiological aspects Risk factors
Online-Zugang:	Volltext
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