Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote [T.sub.H]17 differentiation

Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (TFH cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the [T.sub.H]17 subset of helpe...

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Veröffentlicht in:	Nature immunology 2014-11, Vol.15 (11), p.1079
Hauptverfasser:	Jeltsch, Katharina M, Hu, Desheng, Brenner, Sven, Zoller, Jessica, Heinz, Gitta A, Nagel, Daniel, Vogel, Katharina U, Rehage, Nina, Warth, Sebastian C, Edelmann, Stephanie L, Gloury, Renee, Martin, Nina, Lohs, Claudia, Lech, Maciej, Stehklein, Jenny E, Geerlof, Arie, Kremmer, Elisabeth, Weber, Achim, Anders, Hans-Joachim, Schmitz, Ingo, Schmidt-Supprian, Marc, Fu, Mingui, Holtmann, Helmut, Krappmann, Daniel, Ruland, Jurgen, Kallies, Axel, Heikenwalder, Mathias, Heissmeyer, Vigo
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding proteins Cell differentiation Genetic aspects Properties T cells
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