and [CD8.sup.+] T cell-dependent antiviral immunity requires STIM1 and STIM2

Calcium signaling is critical for lymphocyte function, and intracellular [Ca.sup.2+] concentrations are regulated by store-operated [Ca.sup.2+] entry (SOCE) through [Ca.sup.2+] release-activated [Ca.sup.2+] (CRAC) channels. In patients, loss-of-function mutations in CRAC channel components ORAI1 and...

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Veröffentlicht in:	The Journal of clinical investigation 2014-10, Vol.124 (10), p.4549
Hauptverfasser:	Shaw, Patrick J, Weidinger, Carl, Vaeth, Martin, Luethy, Kevin, Kaech, Susan M, Feske, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4 lymphocytes CD8 lymphocytes Genetic aspects Host-virus relationships Identification and classification Immune system
Online-Zugang:	Volltext
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