Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice
Toxoplasma gondii is a very common obligate single-cell protozoan parasite which induces overproduction of interferon (IFN)-gamma and of other proinflammatory cytokines. Although immunomodulatory role of IFN-gamma favors tryptophan (Trp) degradation via indoleamine-2,3-dioxygenase (IDO) activity and...
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| Veröffentlicht in: | Parasitology research (1987) 2012-10, Vol.111 (4), p.1725-1730 |
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| creator | Engin, Ayse Basak Dogruman-Al, Funda Ercin, Ugur Celebi, Bekir Babur, Cahit Bukan, Neslihan |
| description | Toxoplasma gondii
is a very common obligate single-cell protozoan parasite which induces overproduction of interferon (IFN)-gamma and of other proinflammatory cytokines. Although immunomodulatory role of IFN-gamma favors tryptophan (Trp) degradation via indoleamine-2,3-dioxygenase (IDO) activity and is related with nitric oxide (NO) synthesis, the mechanism of antitoxoplasma activity is complex. In order to characterize the Trp degradation pattern during the acute
T. gondii
infection, serum Trp, kynurenine (Kyn), and urinary biopterin levels of mice were measured. The possible oxidative status was evaluated by the liver, spleen, brain, and serum malondialdehyde (MDA) and NO levels. Increased free radical toxicity may cause elevation in tissue MDA in
T. gondii
-infected mice, while unchanged serum MDA might indicate the increased oxidative stress due to
T. gondii
infection restricted to intracellular area. Elevated serum NO most probably might be due to the formation of reactive nitrogen radicals. The Kyn/Trp ratio was higher in
T. gondii
-infected mice compared to healthy animals (
p
|
| doi_str_mv | 10.1007/s00436-012-3015-6 |
| format | Article |
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is a very common obligate single-cell protozoan parasite which induces overproduction of interferon (IFN)-gamma and of other proinflammatory cytokines. Although immunomodulatory role of IFN-gamma favors tryptophan (Trp) degradation via indoleamine-2,3-dioxygenase (IDO) activity and is related with nitric oxide (NO) synthesis, the mechanism of antitoxoplasma activity is complex. In order to characterize the Trp degradation pattern during the acute
T. gondii
infection, serum Trp, kynurenine (Kyn), and urinary biopterin levels of mice were measured. The possible oxidative status was evaluated by the liver, spleen, brain, and serum malondialdehyde (MDA) and NO levels. Increased free radical toxicity may cause elevation in tissue MDA in
T. gondii
-infected mice, while unchanged serum MDA might indicate the increased oxidative stress due to
T. gondii
infection restricted to intracellular area. Elevated serum NO most probably might be due to the formation of reactive nitrogen radicals. The Kyn/Trp ratio was higher in
T. gondii
-infected mice compared to healthy animals (
p
< 0.05); however, it was not correlated with urinary biopterin. These results suggested that Trp degradation might be promoted by a pathway other than IDO during
T. gondii
infection and the reduction of Trp concentration favors the local immunosuppression and systemic tolerance.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-012-3015-6</identifier><identifier>PMID: 22790966</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animal Structures - pathology ; Animals ; Biological and medical sciences ; Biological response modifiers ; Biomedical and Life Sciences ; Biomedicine ; Biopterins - urine ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Health aspects ; Immunology ; Infection ; Interferon ; Invertebrates ; Ionizing radiation ; Kynurenine - blood ; Male ; Malondialdehyde - analysis ; Malondialdehyde - blood ; Medical Microbiology ; Mice ; Microbiology ; Nitric oxide ; Nitric Oxide - analysis ; Original Paper ; Oxidative Stress ; Toxoplasma - pathogenicity ; Toxoplasmosis, Animal - physiopathology ; Tryptophan ; Tryptophan - blood ; Tryptophan - metabolism</subject><ispartof>Parasitology research (1987), 2012-10, Vol.111 (4), p.1725-1730</ispartof><rights>Springer-Verlag 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-228db83df9abcfb699210448cb9268d92324722c502d7ba372ac32a86ab21ea03</citedby><cites>FETCH-LOGICAL-c441t-228db83df9abcfb699210448cb9268d92324722c502d7ba372ac32a86ab21ea03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-012-3015-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-012-3015-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26362566$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22790966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engin, Ayse Basak</creatorcontrib><creatorcontrib>Dogruman-Al, Funda</creatorcontrib><creatorcontrib>Ercin, Ugur</creatorcontrib><creatorcontrib>Celebi, Bekir</creatorcontrib><creatorcontrib>Babur, Cahit</creatorcontrib><creatorcontrib>Bukan, Neslihan</creatorcontrib><title>Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Toxoplasma gondii
is a very common obligate single-cell protozoan parasite which induces overproduction of interferon (IFN)-gamma and of other proinflammatory cytokines. Although immunomodulatory role of IFN-gamma favors tryptophan (Trp) degradation via indoleamine-2,3-dioxygenase (IDO) activity and is related with nitric oxide (NO) synthesis, the mechanism of antitoxoplasma activity is complex. In order to characterize the Trp degradation pattern during the acute
T. gondii
infection, serum Trp, kynurenine (Kyn), and urinary biopterin levels of mice were measured. The possible oxidative status was evaluated by the liver, spleen, brain, and serum malondialdehyde (MDA) and NO levels. Increased free radical toxicity may cause elevation in tissue MDA in
T. gondii
-infected mice, while unchanged serum MDA might indicate the increased oxidative stress due to
T. gondii
infection restricted to intracellular area. Elevated serum NO most probably might be due to the formation of reactive nitrogen radicals. The Kyn/Trp ratio was higher in
T. gondii
-infected mice compared to healthy animals (
p
< 0.05); however, it was not correlated with urinary biopterin. These results suggested that Trp degradation might be promoted by a pathway other than IDO during
T. gondii
infection and the reduction of Trp concentration favors the local immunosuppression and systemic tolerance.</description><subject>Animal Structures - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological response modifiers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopterins - urine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Health aspects</subject><subject>Immunology</subject><subject>Infection</subject><subject>Interferon</subject><subject>Invertebrates</subject><subject>Ionizing radiation</subject><subject>Kynurenine - blood</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Malondialdehyde - blood</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - analysis</subject><subject>Original Paper</subject><subject>Oxidative Stress</subject><subject>Toxoplasma - pathogenicity</subject><subject>Toxoplasmosis, Animal - physiopathology</subject><subject>Tryptophan</subject><subject>Tryptophan - blood</subject><subject>Tryptophan - metabolism</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFqHSEUhqU0NLdpH6CbIpQsJ9Gj44zLEJq0EMgmXdsz6twa7uigc0vy9vVmkpZCKS4U_b7j4fyEfODsjDPWnRfGpFAN49AIxttGvSIbLgU0XLfta7Jhup4Z5-KYvC3lnjHeKSnfkGOATjOt1IZ8v30IDpfw09OyZF8Kxejokh_nJc0_MFLntxkPRIp0xmXxOdI0UrT7xdO79JDmHZYJ6TZFFwINcfT2CQ6RTsH6d-RoxF3x75_3E_Lt6vPd5Zfm5vb66-XFTWOl5EsD0LuhF27UONhxUFoDZ1L2dtCgeqdBgOwAbMvAdQOKDtAKwF7hANwjEyfk01p3iztvahtpyWinUKy5EJ3Soiptpc7-QdXlfG02RT-Gev-XwFfB5lRK9qOZc5gwPxrOzCEEs4ZgagjmEIJR1fm4OvN-mLz7bbxMvQKnzwAWi7sxY7Sh_OGUUNA-cbBypT7Frc_mPu1zrGP8z--_AAuonmw</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Engin, Ayse Basak</creator><creator>Dogruman-Al, Funda</creator><creator>Ercin, Ugur</creator><creator>Celebi, Bekir</creator><creator>Babur, Cahit</creator><creator>Bukan, Neslihan</creator><general>Springer-Verlag</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20121001</creationdate><title>Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice</title><author>Engin, Ayse Basak ; Dogruman-Al, Funda ; Ercin, Ugur ; Celebi, Bekir ; Babur, Cahit ; Bukan, Neslihan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-228db83df9abcfb699210448cb9268d92324722c502d7ba372ac32a86ab21ea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Structures - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological response modifiers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biopterins - urine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>Health aspects</topic><topic>Immunology</topic><topic>Infection</topic><topic>Interferon</topic><topic>Invertebrates</topic><topic>Ionizing radiation</topic><topic>Kynurenine - blood</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>Malondialdehyde - blood</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - analysis</topic><topic>Original Paper</topic><topic>Oxidative Stress</topic><topic>Toxoplasma - pathogenicity</topic><topic>Toxoplasmosis, Animal - physiopathology</topic><topic>Tryptophan</topic><topic>Tryptophan - blood</topic><topic>Tryptophan - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engin, Ayse Basak</creatorcontrib><creatorcontrib>Dogruman-Al, Funda</creatorcontrib><creatorcontrib>Ercin, Ugur</creatorcontrib><creatorcontrib>Celebi, Bekir</creatorcontrib><creatorcontrib>Babur, Cahit</creatorcontrib><creatorcontrib>Bukan, Neslihan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engin, Ayse Basak</au><au>Dogruman-Al, Funda</au><au>Ercin, Ugur</au><au>Celebi, Bekir</au><au>Babur, Cahit</au><au>Bukan, Neslihan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>111</volume><issue>4</issue><spage>1725</spage><epage>1730</epage><pages>1725-1730</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>Toxoplasma gondii
is a very common obligate single-cell protozoan parasite which induces overproduction of interferon (IFN)-gamma and of other proinflammatory cytokines. Although immunomodulatory role of IFN-gamma favors tryptophan (Trp) degradation via indoleamine-2,3-dioxygenase (IDO) activity and is related with nitric oxide (NO) synthesis, the mechanism of antitoxoplasma activity is complex. In order to characterize the Trp degradation pattern during the acute
T. gondii
infection, serum Trp, kynurenine (Kyn), and urinary biopterin levels of mice were measured. The possible oxidative status was evaluated by the liver, spleen, brain, and serum malondialdehyde (MDA) and NO levels. Increased free radical toxicity may cause elevation in tissue MDA in
T. gondii
-infected mice, while unchanged serum MDA might indicate the increased oxidative stress due to
T. gondii
infection restricted to intracellular area. Elevated serum NO most probably might be due to the formation of reactive nitrogen radicals. The Kyn/Trp ratio was higher in
T. gondii
-infected mice compared to healthy animals (
p
< 0.05); however, it was not correlated with urinary biopterin. These results suggested that Trp degradation might be promoted by a pathway other than IDO during
T. gondii
infection and the reduction of Trp concentration favors the local immunosuppression and systemic tolerance.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22790966</pmid><doi>10.1007/s00436-012-3015-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Parasitology research (1987), 2012-10, Vol.111 (4), p.1725-1730 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A376933725 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animal Structures - pathology Animals Biological and medical sciences Biological response modifiers Biomedical and Life Sciences Biomedicine Biopterins - urine Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Health aspects Immunology Infection Interferon Invertebrates Ionizing radiation Kynurenine - blood Male Malondialdehyde - analysis Malondialdehyde - blood Medical Microbiology Mice Microbiology Nitric oxide Nitric Oxide - analysis Original Paper Oxidative Stress Toxoplasma - pathogenicity Toxoplasmosis, Animal - physiopathology Tryptophan Tryptophan - blood Tryptophan - metabolism |
| title | Oxidative stress and tryptophan degradation pattern of acute Toxoplasma gondii infection in mice |
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