Molecularly imprinted poly(acrylonitrile-co-acrylic acid) matrix with sclareol
There are presented results regarding a new set of molecularly imprinted polymers (MIPs) based on acrylonitrile:acrylic acid (AN:AA) copolymer matrix. As template, it was used sclareol, an important anticancer bioactive compound, never used before for molecular imprinting. An emerging and insufficie...
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| Veröffentlicht in: | Polymer engineering and science 2014-07, Vol.54 (7), p.1484-1494 |
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| creator | Dima, Stefan-Ovidiu Dobre, Tanase Chetraru, Olga Nicolae, Cristian-Andi Spataru, Catalin-Ilie Sarbu, Andrei |
| description | There are presented results regarding a new set of molecularly imprinted polymers (MIPs) based on acrylonitrile:acrylic acid (AN:AA) copolymer matrix. As template, it was used sclareol, an important anticancer bioactive compound, never used before for molecular imprinting. An emerging and insufficient studied MIP preparation method, namely the phase inversion, was used to prepare 0.8 mm spherical sclareol MIPs (S‐MIPs). Three AN:AA copolymers, having the initial monomer ratios 90:10, 80:20, and 70:30, were synthesized by radical copolymerization in emulsion, without emulsifier. After that, each copolymer was dissolved in the presence of the template (sclareol) in dimethylformamide. The imprinting and the morphology of these new materials were analyzed by rheology, elemental analysis, infrared spectroscopy, size exclusion chromatography, thermogravimetric analysis, differential scanning calorimetry, batch rebinding tests, and Scatchard analysis. The conclusion was that the AN:AA‐80:20 matrix proved to be the optimized solution between high rigidity (given by the AN segments) and high affinity for the template (given by AA segments), the average imprinting factor for this system being 2.67. POLYM. ENG. SCI., 54:1484–1494, 2014. © 2013 Society of Plastics Engineers |
| doi_str_mv | 10.1002/pen.23689 |
| format | Article |
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As template, it was used sclareol, an important anticancer bioactive compound, never used before for molecular imprinting. An emerging and insufficient studied MIP preparation method, namely the phase inversion, was used to prepare 0.8 mm spherical sclareol MIPs (S‐MIPs). Three AN:AA copolymers, having the initial monomer ratios 90:10, 80:20, and 70:30, were synthesized by radical copolymerization in emulsion, without emulsifier. After that, each copolymer was dissolved in the presence of the template (sclareol) in dimethylformamide. The imprinting and the morphology of these new materials were analyzed by rheology, elemental analysis, infrared spectroscopy, size exclusion chromatography, thermogravimetric analysis, differential scanning calorimetry, batch rebinding tests, and Scatchard analysis. 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As template, it was used sclareol, an important anticancer bioactive compound, never used before for molecular imprinting. An emerging and insufficient studied MIP preparation method, namely the phase inversion, was used to prepare 0.8 mm spherical sclareol MIPs (S‐MIPs). Three AN:AA copolymers, having the initial monomer ratios 90:10, 80:20, and 70:30, were synthesized by radical copolymerization in emulsion, without emulsifier. After that, each copolymer was dissolved in the presence of the template (sclareol) in dimethylformamide. The imprinting and the morphology of these new materials were analyzed by rheology, elemental analysis, infrared spectroscopy, size exclusion chromatography, thermogravimetric analysis, differential scanning calorimetry, batch rebinding tests, and Scatchard analysis. The conclusion was that the AN:AA‐80:20 matrix proved to be the optimized solution between high rigidity (given by the AN segments) and high affinity for the template (given by AA segments), the average imprinting factor for this system being 2.67. POLYM. ENG. SCI., 54:1484–1494, 2014. © 2013 Society of Plastics Engineers</description><subject>Analysis</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Chemical properties</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Materials research</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polyacrylonitrile</subject><subject>Polymers</subject><subject>Polymers with particular properties</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><subject>Production processes</subject><subject>Rheology</subject><issn>0032-3888</issn><issn>1548-2634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>N95</sourceid><recordid>eNp1kWtL5DAYhcPiwo6XD_6Dgiwo2DFpekk-quiouOMd_RbSNBmzpu2QdBj77311XNmBkUACyXMO78lBaJvgIcE4OZjqZpjQnPEfaECylMVJTtM1NMCYJjFljP1C6yH8xcDSjA_Q-E_rtJo56V0f2XrqbdPpKpq2rt-VyveubWznrdOxauOPC6siqWy1F9USHl6jue2eo6DAQbduE_000gW99XluoIfTk_vjs_jyanR-fHgZq4xQHnNelYZTosrEYJJxQww2ZVIWnCua5rxKCatyykiJSZGWjFHDSpbBzLhglFd0A-0sfCfSaWEb03ZeqtoGJQ5pAflBlwAVr6AmutFeQjBtINcyP1zBw6p0bdVKwd6SAJhOv3YTOQtBnN_dLrP7_7HlLNhGB9iCnTx3YSFZZa18G4LXRkA3tfS9IFi8Vy2gavFRNbC_F-xUBiWd8bJRNnwJEpaTFPMcuIMFN4cc_feG4vpk_M_58wdtgGBfCulfRF7QIhOP45GgT7dH6cXNvbihb73ew7s</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Dima, Stefan-Ovidiu</creator><creator>Dobre, Tanase</creator><creator>Chetraru, Olga</creator><creator>Nicolae, Cristian-Andi</creator><creator>Spataru, Catalin-Ilie</creator><creator>Sarbu, Andrei</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Society of Plastics Engineers, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>N95</scope><scope>XI7</scope><scope>ISR</scope></search><sort><creationdate>201407</creationdate><title>Molecularly imprinted poly(acrylonitrile-co-acrylic acid) matrix with sclareol</title><author>Dima, Stefan-Ovidiu ; Dobre, Tanase ; Chetraru, Olga ; Nicolae, Cristian-Andi ; Spataru, Catalin-Ilie ; Sarbu, Andrei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5139-99dbf931cb2f0159f1f0fb2b799c3469d418d6381b0174b883f8b8502307839d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Chemical properties</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Materials research</topic><topic>Medical sciences</topic><topic>Organic polymers</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polyacrylonitrile</topic><topic>Polymers</topic><topic>Polymers with particular properties</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><topic>Production processes</topic><topic>Rheology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dima, Stefan-Ovidiu</creatorcontrib><creatorcontrib>Dobre, Tanase</creatorcontrib><creatorcontrib>Chetraru, Olga</creatorcontrib><creatorcontrib>Nicolae, Cristian-Andi</creatorcontrib><creatorcontrib>Spataru, Catalin-Ilie</creatorcontrib><creatorcontrib>Sarbu, Andrei</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Gale Business: Insights</collection><collection>Business Insights: Essentials</collection><collection>Gale In Context: Science</collection><jtitle>Polymer engineering and science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dima, Stefan-Ovidiu</au><au>Dobre, Tanase</au><au>Chetraru, Olga</au><au>Nicolae, Cristian-Andi</au><au>Spataru, Catalin-Ilie</au><au>Sarbu, Andrei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecularly imprinted poly(acrylonitrile-co-acrylic acid) matrix with sclareol</atitle><jtitle>Polymer engineering and science</jtitle><addtitle>Polym Eng Sci</addtitle><date>2014-07</date><risdate>2014</risdate><volume>54</volume><issue>7</issue><spage>1484</spage><epage>1494</epage><pages>1484-1494</pages><issn>0032-3888</issn><eissn>1548-2634</eissn><coden>PYESAZ</coden><abstract>There are presented results regarding a new set of molecularly imprinted polymers (MIPs) based on acrylonitrile:acrylic acid (AN:AA) copolymer matrix. As template, it was used sclareol, an important anticancer bioactive compound, never used before for molecular imprinting. An emerging and insufficient studied MIP preparation method, namely the phase inversion, was used to prepare 0.8 mm spherical sclareol MIPs (S‐MIPs). Three AN:AA copolymers, having the initial monomer ratios 90:10, 80:20, and 70:30, were synthesized by radical copolymerization in emulsion, without emulsifier. After that, each copolymer was dissolved in the presence of the template (sclareol) in dimethylformamide. The imprinting and the morphology of these new materials were analyzed by rheology, elemental analysis, infrared spectroscopy, size exclusion chromatography, thermogravimetric analysis, differential scanning calorimetry, batch rebinding tests, and Scatchard analysis. The conclusion was that the AN:AA‐80:20 matrix proved to be the optimized solution between high rigidity (given by the AN segments) and high affinity for the template (given by AA segments), the average imprinting factor for this system being 2.67. POLYM. ENG. SCI., 54:1484–1494, 2014. © 2013 Society of Plastics Engineers</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1002/pen.23689</doi><tpages>11</tpages></addata></record> |
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| subjects | Analysis Applied sciences Biological and medical sciences Chemical properties Exact sciences and technology General pharmacology Materials research Medical sciences Organic polymers Pharmacology. Drug treatments Physicochemistry of polymers Polyacrylonitrile Polymers Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Production processes Rheology |
| title | Molecularly imprinted poly(acrylonitrile-co-acrylic acid) matrix with sclareol |
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