Incidence of postoperative delirium is high even in a population without known risk factors
Purpose Postoperative delirium is a recognized complication in populations at risk. The aim of this study is to assess the prevalence of early postoperative delirium in a population without known risk factors admitted to the ICU for postoperative monitoring after elective major surgery. The secondar...
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| Veröffentlicht in: | Journal of anesthesia 2014-04, Vol.28 (2), p.198-201 |
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| container_title | Journal of anesthesia |
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| creator | Saporito, Andrea Sturini, Evelina |
| description | Purpose
Postoperative delirium is a recognized complication in populations at risk. The aim of this study is to assess the prevalence of early postoperative delirium in a population without known risk factors admitted to the ICU for postoperative monitoring after elective major surgery. The secondary outcome investigated is to identify eventual independent risk factors among demographic data and anesthetic drugs used.
Methods
An observational, prospective study was conducted on a consecutive cohort of patients admitted to our ICU within and for at least 24 h after major surgical procedures. Exclusion criteria were any preexisting predisposing factor for delirium or other potentially confounding neurological dysfunctions. Patients were assessed daily using the confusion assessment method for the ICU scale for 3 days after the surgical procedure. Early postoperative delirium incidence risk factors were then assessed through three different multiple regression models.
Results
According to the confusion assessment method for the ICU scale, 28 % of patients were diagnosed with early postoperative delirium. The use of thiopentone was significantly associated with an eight-fold-higher risk for delirium compared to propofol (57.1 % vs. 7.1 %, RR = 8.0,
χ
2
= 4.256;
df
= 1; 0.05 |
| doi_str_mv | 10.1007/s00540-013-1706-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A372958811</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A372958811</galeid><sourcerecordid>A372958811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-f838d39e700187b90d0d813e4da29c5ea0cb38d7d10e7e338791bd49812de8693</originalsourceid><addsrcrecordid>eNp9kcFq3DAQhkVJabbbPkAvRZCz05FlW9IxhKQNBHppTz0IrTTeVWJLRrIT8vbV4rZQWMIcBDPfPzD6CPnE4JIBiC8ZoG2gAsYrJqCr2jdkwxouK8lbdUY2oMpEdp08J-9zfgCAjjH-jpzXDXSyFWxDft0F6x0GizT2dIp5jhMmM_snpA4Hn_wyUp_pwe8PFJ8wUB-oKeC0DIWKgT77-RCXmT6G-Bxo8vmR9sbOMeUP5G1vhowf_7xb8vP25sf1t-r--9e766v7yjaCz1UvuXRcoQBgUuwUOHCScWycqZVt0YDdFUI4BiiQcykU27lGSVY7lJ3iW3Kx7t2bAbUPfZyTsaPPVl9xUatWynL2llQnqD2Gcu4QA_a-tP_jL0_wpRyO3p4MsDVgU8w5Ya-n5EeTXjQDffSlV1-6-NJHX7otmc9rZlp2I7p_ib-CClCvQC6jsMekH-KSQvnOV7b-Bn9ynyI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Incidence of postoperative delirium is high even in a population without known risk factors</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Saporito, Andrea ; Sturini, Evelina</creator><creatorcontrib>Saporito, Andrea ; Sturini, Evelina</creatorcontrib><description>Purpose
Postoperative delirium is a recognized complication in populations at risk. The aim of this study is to assess the prevalence of early postoperative delirium in a population without known risk factors admitted to the ICU for postoperative monitoring after elective major surgery. The secondary outcome investigated is to identify eventual independent risk factors among demographic data and anesthetic drugs used.
Methods
An observational, prospective study was conducted on a consecutive cohort of patients admitted to our ICU within and for at least 24 h after major surgical procedures. Exclusion criteria were any preexisting predisposing factor for delirium or other potentially confounding neurological dysfunctions. Patients were assessed daily using the confusion assessment method for the ICU scale for 3 days after the surgical procedure. Early postoperative delirium incidence risk factors were then assessed through three different multiple regression models.
Results
According to the confusion assessment method for the ICU scale, 28 % of patients were diagnosed with early postoperative delirium. The use of thiopentone was significantly associated with an eight-fold-higher risk for delirium compared to propofol (57.1 % vs. 7.1 %, RR = 8.0,
χ
2
= 4.256;
df
= 1; 0.05 <
p
< 0.02).
Conclusion
In this study early postoperative delirium was found to be a very common complication after major surgery, even in a population without known risk factors. Thiopentone was independently associated with an increase in its relative risk.</description><identifier>ISSN: 0913-8668</identifier><identifier>EISSN: 1438-8359</identifier><identifier>DOI: 10.1007/s00540-013-1706-5</identifier><identifier>PMID: 24068571</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Anesthesia ; Anesthesia, General - adverse effects ; Anesthesiology ; Anesthetics - adverse effects ; Anesthetics, Combined ; Critical Care Medicine ; Delirium ; Delirium - chemically induced ; Delirium - diagnosis ; Diagnosis ; Elective Surgical Procedures - adverse effects ; Emergency Medicine ; Female ; Health aspects ; Humans ; Incidence ; Intensive ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Pain Medicine ; Patients ; Postoperative Complications - chemically induced ; Postoperative Complications - diagnosis ; Propofol - adverse effects ; Prospective Studies ; Risk Factors ; Thiopental - adverse effects</subject><ispartof>Journal of anesthesia, 2014-04, Vol.28 (2), p.198-201</ispartof><rights>Japanese Society of Anesthesiologists 2013</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-f838d39e700187b90d0d813e4da29c5ea0cb38d7d10e7e338791bd49812de8693</citedby><cites>FETCH-LOGICAL-c473t-f838d39e700187b90d0d813e4da29c5ea0cb38d7d10e7e338791bd49812de8693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00540-013-1706-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00540-013-1706-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24068571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saporito, Andrea</creatorcontrib><creatorcontrib>Sturini, Evelina</creatorcontrib><title>Incidence of postoperative delirium is high even in a population without known risk factors</title><title>Journal of anesthesia</title><addtitle>J Anesth</addtitle><addtitle>J Anesth</addtitle><description>Purpose
Postoperative delirium is a recognized complication in populations at risk. The aim of this study is to assess the prevalence of early postoperative delirium in a population without known risk factors admitted to the ICU for postoperative monitoring after elective major surgery. The secondary outcome investigated is to identify eventual independent risk factors among demographic data and anesthetic drugs used.
Methods
An observational, prospective study was conducted on a consecutive cohort of patients admitted to our ICU within and for at least 24 h after major surgical procedures. Exclusion criteria were any preexisting predisposing factor for delirium or other potentially confounding neurological dysfunctions. Patients were assessed daily using the confusion assessment method for the ICU scale for 3 days after the surgical procedure. Early postoperative delirium incidence risk factors were then assessed through three different multiple regression models.
Results
According to the confusion assessment method for the ICU scale, 28 % of patients were diagnosed with early postoperative delirium. The use of thiopentone was significantly associated with an eight-fold-higher risk for delirium compared to propofol (57.1 % vs. 7.1 %, RR = 8.0,
χ
2
= 4.256;
df
= 1; 0.05 <
p
< 0.02).
Conclusion
In this study early postoperative delirium was found to be a very common complication after major surgery, even in a population without known risk factors. Thiopentone was independently associated with an increase in its relative risk.</description><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia, General - adverse effects</subject><subject>Anesthesiology</subject><subject>Anesthetics - adverse effects</subject><subject>Anesthetics, Combined</subject><subject>Critical Care Medicine</subject><subject>Delirium</subject><subject>Delirium - chemically induced</subject><subject>Delirium - diagnosis</subject><subject>Diagnosis</subject><subject>Elective Surgical Procedures - adverse effects</subject><subject>Emergency Medicine</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Patients</subject><subject>Postoperative Complications - chemically induced</subject><subject>Postoperative Complications - diagnosis</subject><subject>Propofol - adverse effects</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Thiopental - adverse effects</subject><issn>0913-8668</issn><issn>1438-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAQhkVJabbbPkAvRZCz05FlW9IxhKQNBHppTz0IrTTeVWJLRrIT8vbV4rZQWMIcBDPfPzD6CPnE4JIBiC8ZoG2gAsYrJqCr2jdkwxouK8lbdUY2oMpEdp08J-9zfgCAjjH-jpzXDXSyFWxDft0F6x0GizT2dIp5jhMmM_snpA4Hn_wyUp_pwe8PFJ8wUB-oKeC0DIWKgT77-RCXmT6G-Bxo8vmR9sbOMeUP5G1vhowf_7xb8vP25sf1t-r--9e766v7yjaCz1UvuXRcoQBgUuwUOHCScWycqZVt0YDdFUI4BiiQcykU27lGSVY7lJ3iW3Kx7t2bAbUPfZyTsaPPVl9xUatWynL2llQnqD2Gcu4QA_a-tP_jL0_wpRyO3p4MsDVgU8w5Ya-n5EeTXjQDffSlV1-6-NJHX7otmc9rZlp2I7p_ib-CClCvQC6jsMekH-KSQvnOV7b-Bn9ynyI</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Saporito, Andrea</creator><creator>Sturini, Evelina</creator><general>Springer Japan</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140401</creationdate><title>Incidence of postoperative delirium is high even in a population without known risk factors</title><author>Saporito, Andrea ; Sturini, Evelina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-f838d39e700187b90d0d813e4da29c5ea0cb38d7d10e7e338791bd49812de8693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Anesthesia</topic><topic>Anesthesia, General - adverse effects</topic><topic>Anesthesiology</topic><topic>Anesthetics - adverse effects</topic><topic>Anesthetics, Combined</topic><topic>Critical Care Medicine</topic><topic>Delirium</topic><topic>Delirium - chemically induced</topic><topic>Delirium - diagnosis</topic><topic>Diagnosis</topic><topic>Elective Surgical Procedures - adverse effects</topic><topic>Emergency Medicine</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Patients</topic><topic>Postoperative Complications - chemically induced</topic><topic>Postoperative Complications - diagnosis</topic><topic>Propofol - adverse effects</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Thiopental - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saporito, Andrea</creatorcontrib><creatorcontrib>Sturini, Evelina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saporito, Andrea</au><au>Sturini, Evelina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of postoperative delirium is high even in a population without known risk factors</atitle><jtitle>Journal of anesthesia</jtitle><stitle>J Anesth</stitle><addtitle>J Anesth</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>28</volume><issue>2</issue><spage>198</spage><epage>201</epage><pages>198-201</pages><issn>0913-8668</issn><eissn>1438-8359</eissn><abstract>Purpose
Postoperative delirium is a recognized complication in populations at risk. The aim of this study is to assess the prevalence of early postoperative delirium in a population without known risk factors admitted to the ICU for postoperative monitoring after elective major surgery. The secondary outcome investigated is to identify eventual independent risk factors among demographic data and anesthetic drugs used.
Methods
An observational, prospective study was conducted on a consecutive cohort of patients admitted to our ICU within and for at least 24 h after major surgical procedures. Exclusion criteria were any preexisting predisposing factor for delirium or other potentially confounding neurological dysfunctions. Patients were assessed daily using the confusion assessment method for the ICU scale for 3 days after the surgical procedure. Early postoperative delirium incidence risk factors were then assessed through three different multiple regression models.
Results
According to the confusion assessment method for the ICU scale, 28 % of patients were diagnosed with early postoperative delirium. The use of thiopentone was significantly associated with an eight-fold-higher risk for delirium compared to propofol (57.1 % vs. 7.1 %, RR = 8.0,
χ
2
= 4.256;
df
= 1; 0.05 <
p
< 0.02).
Conclusion
In this study early postoperative delirium was found to be a very common complication after major surgery, even in a population without known risk factors. Thiopentone was independently associated with an increase in its relative risk.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24068571</pmid><doi>10.1007/s00540-013-1706-5</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0913-8668 |
| ispartof | Journal of anesthesia, 2014-04, Vol.28 (2), p.198-201 |
| issn | 0913-8668 1438-8359 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A372958811 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Anesthesia Anesthesia, General - adverse effects Anesthesiology Anesthetics - adverse effects Anesthetics, Combined Critical Care Medicine Delirium Delirium - chemically induced Delirium - diagnosis Diagnosis Elective Surgical Procedures - adverse effects Emergency Medicine Female Health aspects Humans Incidence Intensive Male Medicine Medicine & Public Health Middle Aged Original Article Pain Medicine Patients Postoperative Complications - chemically induced Postoperative Complications - diagnosis Propofol - adverse effects Prospective Studies Risk Factors Thiopental - adverse effects |
| title | Incidence of postoperative delirium is high even in a population without known risk factors |
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