Studies on the production feasibility of [sup.64]Cu by reactions on Zn targets in Dhruva research reactor
[sup.64]Cu is an useful radionuclide for both PET imaging and targeted therapy, as it decays by three different modes, namely, electron capture (41%), [β.sup.-] (40%) and positron emission (19%). [sup.64]Cu is generally produced by [sup.64]Ni (p, n) reaction in a cyclotron for medical use. High spec...
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| Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2012-10, Vol.294 (1), p.43 |
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| container_title | Journal of radioanalytical and nuclear chemistry |
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| creator | Vimalnath, K.V Rajeswari, A Jagadeesan, K.C Viju, C Joshi, P.V Venkatesh, Meera |
| description | [sup.64]Cu is an useful radionuclide for both PET imaging and targeted therapy, as it decays by three different modes, namely, electron capture (41%), [β.sup.-] (40%) and positron emission (19%). [sup.64]Cu is generally produced by [sup.64]Ni (p, n) reaction in a cyclotron for medical use. High specific activity 'no carrier added' grade [sup.64]Cu by [sup.64]Zn (n, p) route is an alternative for research studies and was hence explored. 10 mg zinc foil target (48.63% in [sup.64]Zn) was irradiated in the medium flux reactor Dhruva at a thermal neutron flux of ~ 5.6 x [10.sup.13] n [cm.sup.-2] [s.sup.-1] for 3 days. The irradiated Zn foil was dissolved in 5 mL 10 M HCl and [sup.64]Cu was separated by anion exchange chromatography (Dowex 1 x 8; 100-200 mesh) at 3 M HCl conditions. [sup.64]Cu radioactivity content and its radionuclide purity were ascertained by γ-ray spectrometry using HPGe detector coupled to a 4 K multichannel analyser system. Radiochemical separation yielded a radionuclidic purity of 99.9% [sup.64]Cu. Keywords [sup.64]Cu * No carrier added * Reactor production * Radionuclide purity |
| doi_str_mv | 10.1007/s10967-011-1548-2 |
| format | Article |
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[sup.64]Cu is generally produced by [sup.64]Ni (p, n) reaction in a cyclotron for medical use. High specific activity 'no carrier added' grade [sup.64]Cu by [sup.64]Zn (n, p) route is an alternative for research studies and was hence explored. 10 mg zinc foil target (48.63% in [sup.64]Zn) was irradiated in the medium flux reactor Dhruva at a thermal neutron flux of ~ 5.6 x [10.sup.13] n [cm.sup.-2] [s.sup.-1] for 3 days. The irradiated Zn foil was dissolved in 5 mL 10 M HCl and [sup.64]Cu was separated by anion exchange chromatography (Dowex 1 x 8; 100-200 mesh) at 3 M HCl conditions. [sup.64]Cu radioactivity content and its radionuclide purity were ascertained by γ-ray spectrometry using HPGe detector coupled to a 4 K multichannel analyser system. Radiochemical separation yielded a radionuclidic purity of 99.9% [sup.64]Cu. 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[sup.64]Cu is generally produced by [sup.64]Ni (p, n) reaction in a cyclotron for medical use. High specific activity 'no carrier added' grade [sup.64]Cu by [sup.64]Zn (n, p) route is an alternative for research studies and was hence explored. 10 mg zinc foil target (48.63% in [sup.64]Zn) was irradiated in the medium flux reactor Dhruva at a thermal neutron flux of ~ 5.6 x [10.sup.13] n [cm.sup.-2] [s.sup.-1] for 3 days. The irradiated Zn foil was dissolved in 5 mL 10 M HCl and [sup.64]Cu was separated by anion exchange chromatography (Dowex 1 x 8; 100-200 mesh) at 3 M HCl conditions. [sup.64]Cu radioactivity content and its radionuclide purity were ascertained by γ-ray spectrometry using HPGe detector coupled to a 4 K multichannel analyser system. Radiochemical separation yielded a radionuclidic purity of 99.9% [sup.64]Cu. 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[sup.64]Cu is generally produced by [sup.64]Ni (p, n) reaction in a cyclotron for medical use. High specific activity 'no carrier added' grade [sup.64]Cu by [sup.64]Zn (n, p) route is an alternative for research studies and was hence explored. 10 mg zinc foil target (48.63% in [sup.64]Zn) was irradiated in the medium flux reactor Dhruva at a thermal neutron flux of ~ 5.6 x [10.sup.13] n [cm.sup.-2] [s.sup.-1] for 3 days. The irradiated Zn foil was dissolved in 5 mL 10 M HCl and [sup.64]Cu was separated by anion exchange chromatography (Dowex 1 x 8; 100-200 mesh) at 3 M HCl conditions. [sup.64]Cu radioactivity content and its radionuclide purity were ascertained by γ-ray spectrometry using HPGe detector coupled to a 4 K multichannel analyser system. Radiochemical separation yielded a radionuclidic purity of 99.9% [sup.64]Cu. Keywords [sup.64]Cu * No carrier added * Reactor production * Radionuclide purity</abstract><pub>Springer</pub><doi>10.1007/s10967-011-1548-2</doi></addata></record> |
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| subjects | Gamma rays Health aspects PET imaging |
| title | Studies on the production feasibility of [sup.64]Cu by reactions on Zn targets in Dhruva research reactor |
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