Modeling laser irradiation conditions for mucosal tissues in antimicrobial photodynamic therapy
We use computer modeling to analzye empirically selected conditions for antimicrobial photodynamic therapy of mucosal tissues. We calculate the optical and thermal fields for experimental conditions for low-intensity (cold) laser irradiation used in treatment of lesions in mucosal tissues stained by...
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| Veröffentlicht in: | Journal of applied spectroscopy 2012-05, Vol.79 (2), p.288-295 |
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| container_end_page | 295 |
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| container_title | Journal of applied spectroscopy |
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| creator | Zalesskaya, G. A. Astaf’eva, L. G. Plavskii, V. Yu |
| description | We use computer modeling to analzye empirically selected conditions for antimicrobial photodynamic therapy of mucosal tissues. We calculate the optical and thermal fields for experimental conditions for low-intensity (cold) laser irradiation used in treatment of lesions in mucosal tissues stained by methylene blue: λ = 670 nm, power density 150–300 mW/cm
2
, doses 9–18 J/cm
2
; λ = 632.8 nm, 15 mW/cm
2
, dose 4.5 J/cm
2
. For numerical estimates, we used the optical characteristics of methylene blue and three layers of mucosal tissues at the laser radiation wavelengths, and also the thermal characteristics of the tissues. The experimental conditions were optimized using the ratio of the tissue penetration depth for the absorbed optical energy and the penetration depth of methylene blue into the lesion, while maintaining safe tissue heating temperatures. |
| doi_str_mv | 10.1007/s10812-012-9596-0 |
| format | Article |
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2
, doses 9–18 J/cm
2
; λ = 632.8 nm, 15 mW/cm
2
, dose 4.5 J/cm
2
. For numerical estimates, we used the optical characteristics of methylene blue and three layers of mucosal tissues at the laser radiation wavelengths, and also the thermal characteristics of the tissues. The experimental conditions were optimized using the ratio of the tissue penetration depth for the absorbed optical energy and the penetration depth of methylene blue into the lesion, while maintaining safe tissue heating temperatures.</description><identifier>ISSN: 0021-9037</identifier><identifier>EISSN: 1573-8647</identifier><identifier>DOI: 10.1007/s10812-012-9596-0</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Analysis ; Analytical Chemistry ; Atomic/Molecular Structure and Spectra ; Cancer ; Nuclear radiation ; Optical properties ; Photochemotherapy ; Physics ; Physics and Astronomy</subject><ispartof>Journal of applied spectroscopy, 2012-05, Vol.79 (2), p.288-295</ispartof><rights>Springer Science+Business Media, Inc. 2012</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-1deb92a64847f3506635e7ea1c75467a9fed729ef3c0a2816eff5e100442f36a3</citedby><cites>FETCH-LOGICAL-c389t-1deb92a64847f3506635e7ea1c75467a9fed729ef3c0a2816eff5e100442f36a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10812-012-9596-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10812-012-9596-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Zalesskaya, G. A.</creatorcontrib><creatorcontrib>Astaf’eva, L. G.</creatorcontrib><creatorcontrib>Plavskii, V. Yu</creatorcontrib><title>Modeling laser irradiation conditions for mucosal tissues in antimicrobial photodynamic therapy</title><title>Journal of applied spectroscopy</title><addtitle>J Appl Spectrosc</addtitle><description>We use computer modeling to analzye empirically selected conditions for antimicrobial photodynamic therapy of mucosal tissues. We calculate the optical and thermal fields for experimental conditions for low-intensity (cold) laser irradiation used in treatment of lesions in mucosal tissues stained by methylene blue: λ = 670 nm, power density 150–300 mW/cm
2
, doses 9–18 J/cm
2
; λ = 632.8 nm, 15 mW/cm
2
, dose 4.5 J/cm
2
. For numerical estimates, we used the optical characteristics of methylene blue and three layers of mucosal tissues at the laser radiation wavelengths, and also the thermal characteristics of the tissues. The experimental conditions were optimized using the ratio of the tissue penetration depth for the absorbed optical energy and the penetration depth of methylene blue into the lesion, while maintaining safe tissue heating temperatures.</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Cancer</subject><subject>Nuclear radiation</subject><subject>Optical properties</subject><subject>Photochemotherapy</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><issn>0021-9037</issn><issn>1573-8647</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kV1rHCEUhiUk0M3HD-idkKtcTHocZ3S8DCFtAymFNrmWk5njrsusLupC99_HZXuzUIqIcnwe0fMy9lnAvQDQX7KAQbQN1Gl6oxo4YwvRa9kMqtPnbAHQisaA1J_YZc5rADBDCwtmf8SJZh-WfMZMifuUcPJYfAx8jGHyh13mLia-2Y0x48yLz3lHmfvAMRS_8WOK774ebFexxGkfsJZ4WVHC7f6aXTicM938Xa_Y29en18fvzcvPb8-PDy_NKAdTGjHRu2lRdUOnnexBKdmTJhSj7jul0TiadGvIyRGwHYQi53qqP--61kmF8ordHu9d4kzWBxdLwnHj82gfpJJiMKC7St3_g6pjovrmGMj5Wj8R7k6EyhT6U5a4y9k-__51yoojW_uRcyJnt8lvMO2tAHsIyR5DsjUkewjJQnXao5MrG5aU7DruUqid-o_0Ac-YlHI</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Zalesskaya, G. A.</creator><creator>Astaf’eva, L. G.</creator><creator>Plavskii, V. Yu</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20120501</creationdate><title>Modeling laser irradiation conditions for mucosal tissues in antimicrobial photodynamic therapy</title><author>Zalesskaya, G. A. ; Astaf’eva, L. G. ; Plavskii, V. Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-1deb92a64847f3506635e7ea1c75467a9fed729ef3c0a2816eff5e100442f36a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Atomic/Molecular Structure and Spectra</topic><topic>Cancer</topic><topic>Nuclear radiation</topic><topic>Optical properties</topic><topic>Photochemotherapy</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zalesskaya, G. A.</creatorcontrib><creatorcontrib>Astaf’eva, L. G.</creatorcontrib><creatorcontrib>Plavskii, V. Yu</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of applied spectroscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zalesskaya, G. A.</au><au>Astaf’eva, L. G.</au><au>Plavskii, V. Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modeling laser irradiation conditions for mucosal tissues in antimicrobial photodynamic therapy</atitle><jtitle>Journal of applied spectroscopy</jtitle><stitle>J Appl Spectrosc</stitle><date>2012-05-01</date><risdate>2012</risdate><volume>79</volume><issue>2</issue><spage>288</spage><epage>295</epage><pages>288-295</pages><issn>0021-9037</issn><eissn>1573-8647</eissn><abstract>We use computer modeling to analzye empirically selected conditions for antimicrobial photodynamic therapy of mucosal tissues. We calculate the optical and thermal fields for experimental conditions for low-intensity (cold) laser irradiation used in treatment of lesions in mucosal tissues stained by methylene blue: λ = 670 nm, power density 150–300 mW/cm
2
, doses 9–18 J/cm
2
; λ = 632.8 nm, 15 mW/cm
2
, dose 4.5 J/cm
2
. For numerical estimates, we used the optical characteristics of methylene blue and three layers of mucosal tissues at the laser radiation wavelengths, and also the thermal characteristics of the tissues. The experimental conditions were optimized using the ratio of the tissue penetration depth for the absorbed optical energy and the penetration depth of methylene blue into the lesion, while maintaining safe tissue heating temperatures.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s10812-012-9596-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Analysis Analytical Chemistry Atomic/Molecular Structure and Spectra Cancer Nuclear radiation Optical properties Photochemotherapy Physics Physics and Astronomy |
| title | Modeling laser irradiation conditions for mucosal tissues in antimicrobial photodynamic therapy |
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