PTPN 12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling

It is well known that protein tyrosine phosphatases (PTPs) that become oxidized due to exposure to reactive oxygen species (ROS) undergo a conformational change and are inactivated. However, whether PTPs can actively regulate ROS levels in order to prevent PTP inhibition has yet to be investigated....

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Veröffentlicht in:	Oncogene 2014-02, Vol.33 (8), p.1047
Hauptverfasser:	Harris, I.S, Blaser, H, Moreno, J, Treloar, A.E, Gorrini, C, Sasaki, M, Mason, J.M, Knobbe, C.B, Rufini, A, Halle, M, Elia, A.J, Wakeham, A, Tremblay, M.L, Melino, G, Done, S, Mak, T.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Breast cancer Genetic aspects Health aspects Oxidative stress Physiological aspects Protein tyrosine kinase Risk factors
Online-Zugang:	Volltext
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