Age-related deregulation of Aire and peripheral tissue antigen genes in the thymic stroma of non-obese diabetic

Gene expression of peripheral tissue antigens (PTAs) in stromal medullary thymic epithelial cells (mTECs) is a key process to the negative selection of autoreactive thymocytes. This phenomenon was termed "promiscuous gene expression" (PGE), which is partially controlled by the Aire gene. N...

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Veröffentlicht in:	Molecular and cellular biochemistry 2010-09, Vol.342 (1-2), p.21
Hauptverfasser:	Fornari, Thais A, Donate, Paula B, Macedo, Claudia, Marques, Marcia M.C, Magalhaes, Danielle A, Passos, Geraldo A.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoimmunity Gene expression Genes Mice Obesity Type 1 diabetes
Online-Zugang:	Volltext
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