Antitumor effects of the combination of magnetohydrodynamic thermochemotherapy and magnetic resonance tomography
Fe₃O₄ nanoparticles were coated with a layer of citric acid, forming coordination bonds between citrate ions and iron ions. The resulting aqueous citrate ferrite colloid was used as a T₂-weighted MRI negative contrasting agent. Sequential i.v. doses of citrate ferrite and Magnevist led to increases...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2010-10, Vol.44 (6), p.291-295 |
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| creator | Brusentsov, N. A Polyanskii, V. A Pirogov, Yu. A Dubina, A. I Uchevatkin, A. A Kupriyanov, D. A Tishchenko, D. A Nikitin, P. I Brusentsova, T. N Ksenevich, T. I Nikitin, M. P Vol'ter, E. R Ivanov, A. V |
| description | Fe₃O₄ nanoparticles were coated with a layer of citric acid, forming coordination bonds between citrate ions and iron ions. The resulting aqueous citrate ferrite colloid was used as a T₂-weighted MRI negative contrasting agent. Sequential i.v. doses of citrate ferrite and Magnevist led to increases in MRI image contrast for 40 h and brightness for 30 min; scanning using a Bruker Biospec BC 70/30 USR biospectrotomograph yielded enhanced MRI images. This enhancement of MRI images was used to monitor oncogenesis during magnetohydrodynamic thermochemotherapy (MT) of mammary adenocarcinoma Ca 755 in female C57Bl/6j mice. Dextran ferrite colloid containing cyclophosphamide was tested as a magnetically directed antitumor agent using MT. Treatment of non-infiltrating tumors of volume ≈ 30 mm³ with six sessions of MT each lasting 30 min at 46°C led to 40% tumor regression and 300% increases in survival time. Treatment of infiltrating tumors of volume ≈ 300 mm³ in the same conditions yielded a 200% increase in survival time. |
| doi_str_mv | 10.1007/s11094-010-0452-3 |
| format | Article |
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| subjects | Ca 755 Citrate ferrite Citric acid Cyclophosphamide Dextran dextran ferrite Iron compounds Medicine negative MRI Organic Chemistry Pharmacology/Toxicology Pharmacy Tumors |
| title | Antitumor effects of the combination of magnetohydrodynamic thermochemotherapy and magnetic resonance tomography |
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