4-hydroxy-2-quinolones. 179. Synthesis, structure, and anti-inflammatory activity of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid and its derivatives

The synthesis of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid has been carried out and the structure and acid properties studied. Preparative methods for its esterification and amidation are proposed. The anti-inflammatory properties of the synthesized compounds have been evaluated.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2010-12, Vol.46 (8), p.947-956
Hauptverfasser:	Ukrainets, I. V, Mospanova, E. V, Davidenko, A. A, Tkach, A. A, Gorokhova, O. V
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxy-2-oxo-1,2-dihydroquinolin-3-ylacetic acids amidation anti-inflammatory activity Anti-inflammatory drugs Chemistry Chemistry and Materials Science esterification Organic Chemistry Pharmacy X-ray analysis
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Beschreibung
Zusammenfassung:	The synthesis of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid has been carried out and the structure and acid properties studied. Preparative methods for its esterification and amidation are proposed. The anti-inflammatory properties of the synthesized compounds have been evaluated.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-010-0607-x