New method for the synthesis of difficultly available sterically hindered tritium-labeled pyridinium derivatives
Direct phenylation of the nitrogen atom in pyridines was noted in a study of the ion-molecule reactions of free nucleogenic phenyl cations generated by β-decay of tritium in labeled benzene. A one-step synthesis of unreported biologically active tritium-labeled N-phenyl-2,6-lutidinium and 2,4,6-coll...
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| Veröffentlicht in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2010-09, Vol.46 (5), p.547-552 |
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| container_end_page | 552 |
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| container_issue | 5 |
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| container_title | Chemistry of heterocyclic compounds (New York, N.Y. 1965) |
| container_volume | 46 |
| creator | Shchepina, N. E Avrorin, V. V Badun, G. A Fedoseev, V. M Lewis, S. B |
| description | Direct phenylation of the nitrogen atom in pyridines was noted in a study of the ion-molecule reactions of free nucleogenic phenyl cations generated by β-decay of tritium in labeled benzene. A one-step synthesis of unreported biologically active tritium-labeled N-phenyl-2,6-lutidinium and 2,4,6-collidi-nium salts. Steric factors, which significantly reduce the yield in the case of sym-collidine, play a major role in the direct phenylation of nitrogen. |
| doi_str_mv | 10.1007/s10593-010-0544-8 |
| format | Article |
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E ; Avrorin, V. V ; Badun, G. A ; Fedoseev, V. M ; Lewis, S. B</creator><creatorcontrib>Shchepina, N. E ; Avrorin, V. V ; Badun, G. A ; Fedoseev, V. M ; Lewis, S. B</creatorcontrib><description>Direct phenylation of the nitrogen atom in pyridines was noted in a study of the ion-molecule reactions of free nucleogenic phenyl cations generated by β-decay of tritium in labeled benzene. A one-step synthesis of unreported biologically active tritium-labeled N-phenyl-2,6-lutidinium and 2,4,6-collidi-nium salts. Steric factors, which significantly reduce the yield in the case of sym-collidine, play a major role in the direct phenylation of nitrogen.</description><identifier>ISSN: 0009-3122</identifier><identifier>EISSN: 1573-8353</identifier><identifier>DOI: 10.1007/s10593-010-0544-8</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Analysis ; Chemistry ; Chemistry and Materials Science ; direct phenylation of pyridine nitrogen atom ; Gene therapy ; Methods ; Nitrogen ; nucleogenic phenyl cations. 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Steric factors, which significantly reduce the yield in the case of sym-collidine, play a major role in the direct phenylation of nitrogen.</description><subject>Analysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>direct phenylation of pyridine nitrogen atom</subject><subject>Gene therapy</subject><subject>Methods</subject><subject>Nitrogen</subject><subject>nucleogenic phenyl cations. N-phenyl-2,6-lutidinium and N-phenyl-2,4,6-collidinium salts</subject><subject>Organic Chemistry</subject><subject>Pharmacy</subject><subject>Pyridine</subject><subject>tritium</subject><issn>0009-3122</issn><issn>1573-8353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kctqHDEQRUWIIRPbH5BVBFnLKT16pF4akxeYZJF4LdR6zJTpxyBpJszfW0NnEwihFkVdzhGIS8g7DnccQH8sHLpeMuDAoFOKmVdkwzstmZGdfE02ANAzyYV4Q96W8txOzY3akMP3-JtOse6XQNOSad1HWs5zWwULXRINmBL641jHM3Unh6MbxobUmNG7sYV7nEPMMdCaseJxYo2IY7sP54wB5xbRBuDJVTzFckOukhtLvP2zr8nT50-_Hr6yxx9fvj3cPzIvdV9Z0m0CHwbvhqSd0mC4UGZQEUTYQie3wWux5QGkiQG8d0oILp3xgwxgenlNPqzv7twYLc5pqdn5CYu397LTINUWLtTdP6g2IU7olzkmbPlfAl8Fn5dSckz2kHFy-Ww52EsTdm3CtibspQlrmiNWpzR23sVsn5djntvv_yu9X6XkFut2GYt9-imAS-CmV73h8gWFC5Zu</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Shchepina, N. E</creator><creator>Avrorin, V. V</creator><creator>Badun, G. 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| identifier | ISSN: 0009-3122 |
| ispartof | Chemistry of heterocyclic compounds (New York, N.Y. 1965), 2010-09, Vol.46 (5), p.547-552 |
| issn | 0009-3122 1573-8353 |
| language | eng |
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| subjects | Analysis Chemistry Chemistry and Materials Science direct phenylation of pyridine nitrogen atom Gene therapy Methods Nitrogen nucleogenic phenyl cations. N-phenyl-2,6-lutidinium and N-phenyl-2,4,6-collidinium salts Organic Chemistry Pharmacy Pyridine tritium |
| title | New method for the synthesis of difficultly available sterically hindered tritium-labeled pyridinium derivatives |
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