New index of pain triggered by spinal activation of voltage-dependent sodium channels

Voltage-dependent sodium channels (VDSCs) are crucial for pain generation. Here, to develop a new behavioral index of pain induced by spinal VDSC activation, we examined whether intrathecal veratridine injection produced nociceptive behavior. Intrathecal injection of the VDSC opener veratridine in m...

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Veröffentlicht in:	Journal of anesthesia 2013-12, Vol.27 (6), p.939-941
Hauptverfasser:	Enomoto, Ryugo, Tsukamoto, Mina, Shimoshige, Yukinori, Aoki, Toshiaki, Matsuoka, Nobuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline - pharmacology Anesthesiology Animals Critical Care Medicine Emergency Medicine gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacology Injections, Spinal Intensive Lidocaine - pharmacology Male Medicine Medicine & Public Health Mexiletine - pharmacology Mice Mice, Inbred ICR Morphine - pharmacology Nociceptive Pain - chemically induced Nociceptive Pain - drug therapy Pain Pain Management - methods Pain Measurement - methods Pain Medicine Physiological aspects Pregabalin Risk factors Short Communication Sodium channels Spinal cord Spine - drug effects Spine - metabolism Voltage-Gated Sodium Channel Agonists - pharmacology Voltage-Gated Sodium Channels - metabolism
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