Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type [Ca.sup.2+] channels

The role of voltage-gated [Ca.sup.2+] channels (VGCCs) in spontaneous miniature neurotransmitter release is incompletely understood. We found that stochastic opening of P/Q-, N- and R-type VGCCs accounts for 50% of all spontaneous glutamate release at rat cultured hippocampal synapses, and that R-ty...

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Veröffentlicht in:	Nature neuroscience 2013-12, Vol.16 (12), p.1754
Hauptverfasser:	Ermolyuk, Yaroslav S, Alder, Felicity G, Surges, Rainer, Pavlov, Ivan Y, Timofeeva, Yulia, Kullmann, Dimitri M, Volynski, Kirill E
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium channels Exocytosis Glutamate Health aspects Physiological aspects
Online-Zugang:	Volltext
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