Effects of Liquid Crystal Systems Based on Cholesterol Esters on Skin Permeability

The mechanisms of the influences of liquid crystal systems based on cholesterol esters on skin permeability were investigated. The effects of liquid crystal systems based on cholesterol esters on the transcutaneous penetration of phenazepam from transdermal therapeutic patches were studied in in vitro conditions. Changes in the fluidity of phospholipid liposomes and liposomes prepared from stratum corneum lipids were studied using fluorescence spectroscopy. Liquid crystal systems based on cholesterol were shown to be effective enhancers of skin permeability.