Cooperation between RUNX1-ET09a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia

Fusion protein RUNX1-ETO (AML1-ETO, RUNX1-RUNX1T1) is expressed as the result of the 8q22;21q22 translocation [t(8;21)], which is one of the most common chromosomal abnormalities found in acute myeloid leukemia. RUNX1-ETO is thought to promote leukemia development through the aberrant regulation of...

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Veröffentlicht in:	PLoS genetics 2013-10, Vol.9 (10)
Hauptverfasser:	DeKelver, Russell C, Lewin, Benjamin, Lam, Kentson, Komeno, Yukiko, Yan, Ming, Rundle, Chandler, Lo, Miao-Chia, Zhang, Dong-Er
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Genetic aspects Genetic regulation Genetic transcription
Online-Zugang:	Volltext
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