In vitro release of tinidazole from polyvinyl alcohol and polvinylpyrrolidine strips- local drug delivery system to treat periodontal pockets

Background: Local drug delivery systems have been investigated in the release of antimicrobials since decades to treat periodontal pockets in periodontal diseases. Aims: The purpose of this in-vitro study is to formulate polyvinyl alcohol strips containing tinidazole. Materials & Methods: Polyvinyl alcohol films containing tinidazole were prepared by dissolving polyvinyl alcohol and polyvinyl pyrolidone powder in water and were slightly warmed on a water bath. The polymeric solution containing tinidazole was then poured on to rectangular slab designed glass molds and was kept overnight with inverted funnel to check evaporation. The release of the drug was analyzed by UV spectrophotometer. Results: The PVA strips had good content uniformity, thickness and folding endurance. Highest level of tinidazole was released during the first 24 h period. Therapeutic levels of the tinidazole continued to be released during the subsequent 9 days period and were shown to be biologically active. Conclusion: It can be concluded that PVA strips containing Tinidazole can be used as local drug delivery system. Key Words: Local drug delivery; polyvinyl alcohol strips; tinidazole