Experimental pharmacokinetics of niferidil upon intravenous administration
The kinetics of niferidil concentration change in blood serum, organs, and urine of rats was studied after i.v. administration at a dose of 5 mg/kg. The blood concentration profile was shown to be described by a bi-exponential equation corresponding to a two-compartment model. Niferidil disappeared...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical chemistry journal 2013-07, Vol.47 (4), p.202-204 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 204 |
|---|---|
| container_issue | 4 |
| container_start_page | 202 |
| container_title | Pharmaceutical chemistry journal |
| container_volume | 47 |
| creator | Filimonova, S. M. Bogomolova, N. S. Chistyakov, V. V. |
| description | The kinetics of niferidil concentration change in blood serum, organs, and urine of rats was studied after i.v. administration at a dose of 5 mg/kg. The blood concentration profile was shown to be described by a bi-exponential equation corresponding to a two-compartment model. Niferidil disappeared quickly from the blood pool with a distribution half-life of 5.13 min. The elimination half-life from blood was 23.3 min. Niferidil penetrated rapidly into organs such as the liver, kidneys, and heart. The concentration calculated per gram of organ 30 min after i.v. administration was six times greater than that in blood (in 1 mL). Accumulation in these organs was not observed. The elimination half-life from the organs was about 1 h. Niferidil was not detected in brain tissue. Niferidil was excreted after i.v. administration unchanged in urine in small amounts. About 10% of the injected dose was eliminated after 24 h. Niferidil was not found in feces. |
| doi_str_mv | 10.1007/s11094-013-0927-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A344828135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A344828135</galeid><sourcerecordid>A344828135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-d598fc2c8204aed0c9416fe37716ddfc110752bb9b3bfc18adf69e503f723f13</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWKs_wNuC59RJsulujqXULwpeevAWsvmoqbvJstmK_nsj60UQyWHI8D4zzIPQNYEFAahuEyEgSgyEYRC0wnCCZoRXDAtg5BTNAATBhMPLObpI6QCQKUZn6Gnz0dvBdzaMqi36VzV0Ssc3H-zodSqiK4J3OWB8Wxz7GAofxkG92xCPqVCm88Gn3Bh9DJfozKk22aufOke7u81u_YC3z_eP69UWa8b5iA0XtdNU1xRKZQ1oUZKls6yqyNIYp_MhFadNIxrW5F-tjFsKy4G5ijJH2BzdTGP3qrXSBxfzft35pOWKlWVNa8J4Ti3-SOVnbOd1DNb53P8FkAnQQ0xpsE72WYsaPiUB-a1YToplViy_FUvIDJ2YlLNhbwd5iMch5OP_gb4AnRd_PQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Experimental pharmacokinetics of niferidil upon intravenous administration</title><source>Springer Nature - Complete Springer Journals</source><creator>Filimonova, S. M. ; Bogomolova, N. S. ; Chistyakov, V. V.</creator><creatorcontrib>Filimonova, S. M. ; Bogomolova, N. S. ; Chistyakov, V. V.</creatorcontrib><description>The kinetics of niferidil concentration change in blood serum, organs, and urine of rats was studied after i.v. administration at a dose of 5 mg/kg. The blood concentration profile was shown to be described by a bi-exponential equation corresponding to a two-compartment model. Niferidil disappeared quickly from the blood pool with a distribution half-life of 5.13 min. The elimination half-life from blood was 23.3 min. Niferidil penetrated rapidly into organs such as the liver, kidneys, and heart. The concentration calculated per gram of organ 30 min after i.v. administration was six times greater than that in blood (in 1 mL). Accumulation in these organs was not observed. The elimination half-life from the organs was about 1 h. Niferidil was not detected in brain tissue. Niferidil was excreted after i.v. administration unchanged in urine in small amounts. About 10% of the injected dose was eliminated after 24 h. Niferidil was not found in feces.</description><identifier>ISSN: 0091-150X</identifier><identifier>EISSN: 1573-9031</identifier><identifier>DOI: 10.1007/s11094-013-0927-0</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Anti-arrhythmia drugs ; Biological products ; Medicine ; Organic Chemistry ; Pharmacology/Toxicology ; Pharmacy</subject><ispartof>Pharmaceutical chemistry journal, 2013-07, Vol.47 (4), p.202-204</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-d598fc2c8204aed0c9416fe37716ddfc110752bb9b3bfc18adf69e503f723f13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11094-013-0927-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11094-013-0927-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Filimonova, S. M.</creatorcontrib><creatorcontrib>Bogomolova, N. S.</creatorcontrib><creatorcontrib>Chistyakov, V. V.</creatorcontrib><title>Experimental pharmacokinetics of niferidil upon intravenous administration</title><title>Pharmaceutical chemistry journal</title><addtitle>Pharm Chem J</addtitle><description>The kinetics of niferidil concentration change in blood serum, organs, and urine of rats was studied after i.v. administration at a dose of 5 mg/kg. The blood concentration profile was shown to be described by a bi-exponential equation corresponding to a two-compartment model. Niferidil disappeared quickly from the blood pool with a distribution half-life of 5.13 min. The elimination half-life from blood was 23.3 min. Niferidil penetrated rapidly into organs such as the liver, kidneys, and heart. The concentration calculated per gram of organ 30 min after i.v. administration was six times greater than that in blood (in 1 mL). Accumulation in these organs was not observed. The elimination half-life from the organs was about 1 h. Niferidil was not detected in brain tissue. Niferidil was excreted after i.v. administration unchanged in urine in small amounts. About 10% of the injected dose was eliminated after 24 h. Niferidil was not found in feces.</description><subject>Anti-arrhythmia drugs</subject><subject>Biological products</subject><subject>Medicine</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWKs_wNuC59RJsulujqXULwpeevAWsvmoqbvJstmK_nsj60UQyWHI8D4zzIPQNYEFAahuEyEgSgyEYRC0wnCCZoRXDAtg5BTNAATBhMPLObpI6QCQKUZn6Gnz0dvBdzaMqi36VzV0Ssc3H-zodSqiK4J3OWB8Wxz7GAofxkG92xCPqVCm88Gn3Bh9DJfozKk22aufOke7u81u_YC3z_eP69UWa8b5iA0XtdNU1xRKZQ1oUZKls6yqyNIYp_MhFadNIxrW5F-tjFsKy4G5ijJH2BzdTGP3qrXSBxfzft35pOWKlWVNa8J4Ti3-SOVnbOd1DNb53P8FkAnQQ0xpsE72WYsaPiUB-a1YToplViy_FUvIDJ2YlLNhbwd5iMch5OP_gb4AnRd_PQ</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Filimonova, S. M.</creator><creator>Bogomolova, N. S.</creator><creator>Chistyakov, V. V.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20130701</creationdate><title>Experimental pharmacokinetics of niferidil upon intravenous administration</title><author>Filimonova, S. M. ; Bogomolova, N. S. ; Chistyakov, V. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-d598fc2c8204aed0c9416fe37716ddfc110752bb9b3bfc18adf69e503f723f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anti-arrhythmia drugs</topic><topic>Biological products</topic><topic>Medicine</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filimonova, S. M.</creatorcontrib><creatorcontrib>Bogomolova, N. S.</creatorcontrib><creatorcontrib>Chistyakov, V. V.</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filimonova, S. M.</au><au>Bogomolova, N. S.</au><au>Chistyakov, V. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental pharmacokinetics of niferidil upon intravenous administration</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2013-07-01</date><risdate>2013</risdate><volume>47</volume><issue>4</issue><spage>202</spage><epage>204</epage><pages>202-204</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>The kinetics of niferidil concentration change in blood serum, organs, and urine of rats was studied after i.v. administration at a dose of 5 mg/kg. The blood concentration profile was shown to be described by a bi-exponential equation corresponding to a two-compartment model. Niferidil disappeared quickly from the blood pool with a distribution half-life of 5.13 min. The elimination half-life from blood was 23.3 min. Niferidil penetrated rapidly into organs such as the liver, kidneys, and heart. The concentration calculated per gram of organ 30 min after i.v. administration was six times greater than that in blood (in 1 mL). Accumulation in these organs was not observed. The elimination half-life from the organs was about 1 h. Niferidil was not detected in brain tissue. Niferidil was excreted after i.v. administration unchanged in urine in small amounts. About 10% of the injected dose was eliminated after 24 h. Niferidil was not found in feces.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s11094-013-0927-0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-150X |
| ispartof | Pharmaceutical chemistry journal, 2013-07, Vol.47 (4), p.202-204 |
| issn | 0091-150X 1573-9031 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A344828135 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Anti-arrhythmia drugs Biological products Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy |
| title | Experimental pharmacokinetics of niferidil upon intravenous administration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A40%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20pharmacokinetics%20of%20niferidil%20upon%20intravenous%20administration&rft.jtitle=Pharmaceutical%20chemistry%20journal&rft.au=Filimonova,%20S.%20M.&rft.date=2013-07-01&rft.volume=47&rft.issue=4&rft.spage=202&rft.epage=204&rft.pages=202-204&rft.issn=0091-150X&rft.eissn=1573-9031&rft_id=info:doi/10.1007/s11094-013-0927-0&rft_dat=%3Cgale_cross%3EA344828135%3C/gale_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A344828135&rfr_iscdi=true |