Nck-mediated recruitment of BCAP to the BCR regulates the PIK-Akt pathway in B cells

The adaptor Nck links receptor signaling to cytoskeleton regulation. Here we found that Nck also controlled the phosphatidylinositol-3-OH kinase (PI(3)K)-kinase Akt pathway by recruiting the adaptor BCAP after activation of B cells. Nck bound directly to the B cell antigen receptor (BCR) via the non...

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Veröffentlicht in:	Nature immunology 2013-09, Vol.14 (9), p.966
Hauptverfasser:	Castello, Angelo, Gaya, Mauro, Tucholski, Johannes, Oellerich, Thomas, Lu, Kun-Hui, Tafuri, Anna, Pawson, Tony, Wienands, Jurgen, Engelke, Michael, Batista, Facundo D
Format:	Artikel
Sprache:	eng
Schlagworte:	B cells Cellular signal transduction Genetic aspects Physiological aspects
Online-Zugang:	Volltext
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