Comparable efficacy of topical eprinomectin and permethrin for treatment of sarcoptic mange in dogs/Usporedna ucinkovitost eprinomektina i permetrina u lijecenju sarkoptoze pasa

The present study was conducted to evaluate the comparative efficacy of topically applied eprinomectin and permethrin for treatment of naturally occuring sarcoptic mange in dogs. A total of 24 dogs of various breeds, age and of both sexes were enrolled. Diagnosis of naturally occuring sarcoptic mange in dogs was made by identifying skin scrapings. All cases were subjected to scoring of the relevant significant clinical signs of scabies such as erythema, pruritis, alopecia, hyperpigmentation and crusting for the whole duration of the study. Dogs in group I (n = 9) received 0.5 mg/kg eprinomectin (5 mg/mL) topically once a week, and group II (n = 8) permethrin at a dosage of 20 mg/kg (100 mg/mL) topicallly once a week, both for a total of 4 weeks. Dogs in group III (n = 7) did not receive any treatment and were left as the control. All the scoring results were statistically evaluated on day 0 and 70, and revealed eprinomectin as the most effective group for evaluating clinical recovery (P