Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial
Purpose Chemoradiotherapy (CRT)-induced oral mucositis (OM) adversely affects a patient’s oral functions and quality of life (QOL). Low-level laser therapy (LLLT) showed some preventive and curative effects against clinically reported objective measures of OM in few trials including our recently pub...
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| Veröffentlicht in: | Supportive care in cancer 2013-05, Vol.21 (5), p.1421-1428 |
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| creator | Gautam, Ajay Prashad Fernandes, Donald J. Vidyasagar, Mamidipudi S. Maiya, Arun G. Nigudgi, Shantling |
| description | Purpose
Chemoradiotherapy (CRT)-induced oral mucositis (OM) adversely affects a patient’s oral functions and quality of life (QOL). Low-level laser therapy (LLLT) showed some preventive and curative effects against clinically reported objective measures of OM in few trials including our recently published study. There is dearth of evidence regarding the effects of LLLT on patient’s subjective experience of OM and QOL. Hence, we did this study to evaluate the effects of LLLT on a patient’s reported measures of OM and QOL in head and neck cancer (HNC) patients receiving CRT.
Methods
This triple blinded study randomized 220 HNC patients scheduled for CRT (three weekly Cisplatin + RT = 66 Gray (2 Gy/session), five fractions/week for 6.5 weeks, total 33 fractions) into laser (110) and placebo (110) groups. The laser group received LLLT (Technomed Electronics Advanced Laser Therapy 1000, He–Ne,
λ
= 632.8 nm, power density = 24 mW/cm
2
, dosage = 3.0 J at each point, total dose/session = 36–40 J, spot size 1 cm
2
, irradiation time/point 125 s) before each radiation session, while the placebo group did not receive laser therapy. Methodology was similar to our recently published study (Gautam et al. Radiother Oncol 104:349–354,
2012
). In this part of our study, a blinded assessor collected subjective outcomes of the patient’s reported measures of OM using Oral Mucositis Weekly Questionnaire-Head and Neck (OMWQ-HN) and QOL using Functional Assessment of Cancer Treatment-Head and Neck (FACT-HN) Questionnaire. Data were analyzed using repeated measure ANOVA through general linear model. Statistical significance was kept at
p
|
| doi_str_mv | 10.1007/s00520-012-1684-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A336672549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A336672549</galeid><sourcerecordid>A336672549</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-a55594c5f70c73cebed7cb752f9f4c487c6c1f898c12a6fbe6aa9478cab8e3bb3</originalsourceid><addsrcrecordid>eNp9kU2O1DAQhSMEYpqBA7BBllhnsGMnTpaj0fAjjcQG1pZTKXd7cOzGdgY1Kw7BhbgKJ8E9aZCQEPLCVtX7Xln1quo5oxeMUvkqUdo2tKasqVnXi1o8qDZMcF5LzoeH1YYOgtWCt-1Z9SSlW0qZlG3zuDpreNOIrh821Y9rYxAyCYa48KV2eIeOOJ0wkrzDqPcHEjzZ62zRZxJxH2LGicyo0xIxHbkQtSPzAiHZbBPRfiKfF-1sPty7WoPEerJDPd33PMInAtpDGXHyTcUY0N5ZvyWww7k4Tjac5v_89l2TWMgw269lNASfY3CuPHO02j2tHhntEj473efVx9fXH67e1jfv37y7urypQTCWa9227SCgNZKC5IAjThLGsg4zGAGil9ABM_3QA2t0Z0bstB6E7EGPPfJx5OfVy9V3qx0q603IUcNsE6hLzrtONq0YiuriH6pyJpxt-ToaW-p_AWwFIIaUIhq1j3bW8aAYVceU1ZqyKimrY8pKFObFyuyXccbpD_E71iJoVkEqLb_FqG7DEn1Zz39cfwFCurh2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Gautam, Ajay Prashad ; Fernandes, Donald J. ; Vidyasagar, Mamidipudi S. ; Maiya, Arun G. ; Nigudgi, Shantling</creator><creatorcontrib>Gautam, Ajay Prashad ; Fernandes, Donald J. ; Vidyasagar, Mamidipudi S. ; Maiya, Arun G. ; Nigudgi, Shantling</creatorcontrib><description>Purpose
Chemoradiotherapy (CRT)-induced oral mucositis (OM) adversely affects a patient’s oral functions and quality of life (QOL). Low-level laser therapy (LLLT) showed some preventive and curative effects against clinically reported objective measures of OM in few trials including our recently published study. There is dearth of evidence regarding the effects of LLLT on patient’s subjective experience of OM and QOL. Hence, we did this study to evaluate the effects of LLLT on a patient’s reported measures of OM and QOL in head and neck cancer (HNC) patients receiving CRT.
Methods
This triple blinded study randomized 220 HNC patients scheduled for CRT (three weekly Cisplatin + RT = 66 Gray (2 Gy/session), five fractions/week for 6.5 weeks, total 33 fractions) into laser (110) and placebo (110) groups. The laser group received LLLT (Technomed Electronics Advanced Laser Therapy 1000, He–Ne,
λ
= 632.8 nm, power density = 24 mW/cm
2
, dosage = 3.0 J at each point, total dose/session = 36–40 J, spot size 1 cm
2
, irradiation time/point 125 s) before each radiation session, while the placebo group did not receive laser therapy. Methodology was similar to our recently published study (Gautam et al. Radiother Oncol 104:349–354,
2012
). In this part of our study, a blinded assessor collected subjective outcomes of the patient’s reported measures of OM using Oral Mucositis Weekly Questionnaire-Head and Neck (OMWQ-HN) and QOL using Functional Assessment of Cancer Treatment-Head and Neck (FACT-HN) Questionnaire. Data were analyzed using repeated measure ANOVA through general linear model. Statistical significance was kept at
p
< 0.05.
Results
Results analysis revealed that OMWQ-HN (
F
= 12.199,
df
= 6,1314,
p
< 0.001) and FACT-HN (
p
< 0.05) scores were significantly lower in LLLT than placebo group patients. Also, a significant reduction (
p
< 0.001) in incidence of severe OM, need for opioid analgesics, and total parenteral nutrition was observed.
Conclusions
LLLT was effective in improving the patient’s subjective experience of OM and QOL in HNC patients receiving CRT.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-012-1684-4</identifier><identifier>PMID: 23224689</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Analgesics, Opioid - therapeutic use ; Analysis ; Analysis of Variance ; Cancer ; Cancer patients ; Care and treatment ; Chemoradiotherapy - adverse effects ; Chemoradiotherapy - methods ; Cisplatin ; Double-Blind Method ; Female ; Head and neck cancer ; Head and Neck Neoplasms - therapy ; Humans ; Lasers in surgery ; Linear Models ; Low-Level Light Therapy - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nuclear radiation ; Nursing ; Nursing Research ; Oncology ; Opioids ; Original Article ; Pain Medicine ; Parenteral Nutrition, Total - methods ; Quality of Life ; Rehabilitation Medicine ; Severity of Illness Index ; Stomatitis ; Stomatitis - etiology ; Stomatitis - pathology ; Stomatitis - radiotherapy ; Surveys and Questionnaires ; Treatment Outcome</subject><ispartof>Supportive care in cancer, 2013-05, Vol.21 (5), p.1421-1428</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-a55594c5f70c73cebed7cb752f9f4c487c6c1f898c12a6fbe6aa9478cab8e3bb3</citedby><cites>FETCH-LOGICAL-c411t-a55594c5f70c73cebed7cb752f9f4c487c6c1f898c12a6fbe6aa9478cab8e3bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-012-1684-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-012-1684-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23224689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gautam, Ajay Prashad</creatorcontrib><creatorcontrib>Fernandes, Donald J.</creatorcontrib><creatorcontrib>Vidyasagar, Mamidipudi S.</creatorcontrib><creatorcontrib>Maiya, Arun G.</creatorcontrib><creatorcontrib>Nigudgi, Shantling</creatorcontrib><title>Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Chemoradiotherapy (CRT)-induced oral mucositis (OM) adversely affects a patient’s oral functions and quality of life (QOL). Low-level laser therapy (LLLT) showed some preventive and curative effects against clinically reported objective measures of OM in few trials including our recently published study. There is dearth of evidence regarding the effects of LLLT on patient’s subjective experience of OM and QOL. Hence, we did this study to evaluate the effects of LLLT on a patient’s reported measures of OM and QOL in head and neck cancer (HNC) patients receiving CRT.
Methods
This triple blinded study randomized 220 HNC patients scheduled for CRT (three weekly Cisplatin + RT = 66 Gray (2 Gy/session), five fractions/week for 6.5 weeks, total 33 fractions) into laser (110) and placebo (110) groups. The laser group received LLLT (Technomed Electronics Advanced Laser Therapy 1000, He–Ne,
λ
= 632.8 nm, power density = 24 mW/cm
2
, dosage = 3.0 J at each point, total dose/session = 36–40 J, spot size 1 cm
2
, irradiation time/point 125 s) before each radiation session, while the placebo group did not receive laser therapy. Methodology was similar to our recently published study (Gautam et al. Radiother Oncol 104:349–354,
2012
). In this part of our study, a blinded assessor collected subjective outcomes of the patient’s reported measures of OM using Oral Mucositis Weekly Questionnaire-Head and Neck (OMWQ-HN) and QOL using Functional Assessment of Cancer Treatment-Head and Neck (FACT-HN) Questionnaire. Data were analyzed using repeated measure ANOVA through general linear model. Statistical significance was kept at
p
< 0.05.
Results
Results analysis revealed that OMWQ-HN (
F
= 12.199,
df
= 6,1314,
p
< 0.001) and FACT-HN (
p
< 0.05) scores were significantly lower in LLLT than placebo group patients. Also, a significant reduction (
p
< 0.001) in incidence of severe OM, need for opioid analgesics, and total parenteral nutrition was observed.
Conclusions
LLLT was effective in improving the patient’s subjective experience of OM and QOL in HNC patients receiving CRT.</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Analysis</subject><subject>Analysis of Variance</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>Chemoradiotherapy - adverse effects</subject><subject>Chemoradiotherapy - methods</subject><subject>Cisplatin</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Head and neck cancer</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Lasers in surgery</subject><subject>Linear Models</subject><subject>Low-Level Light Therapy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nuclear radiation</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Opioids</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Parenteral Nutrition, Total - methods</subject><subject>Quality of Life</subject><subject>Rehabilitation Medicine</subject><subject>Severity of Illness Index</subject><subject>Stomatitis</subject><subject>Stomatitis - etiology</subject><subject>Stomatitis - pathology</subject><subject>Stomatitis - radiotherapy</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhSMEYpqBA7BBllhnsGMnTpaj0fAjjcQG1pZTKXd7cOzGdgY1Kw7BhbgKJ8E9aZCQEPLCVtX7Xln1quo5oxeMUvkqUdo2tKasqVnXi1o8qDZMcF5LzoeH1YYOgtWCt-1Z9SSlW0qZlG3zuDpreNOIrh821Y9rYxAyCYa48KV2eIeOOJ0wkrzDqPcHEjzZ62zRZxJxH2LGicyo0xIxHbkQtSPzAiHZbBPRfiKfF-1sPty7WoPEerJDPd33PMInAtpDGXHyTcUY0N5ZvyWww7k4Tjac5v_89l2TWMgw269lNASfY3CuPHO02j2tHhntEj473efVx9fXH67e1jfv37y7urypQTCWa9227SCgNZKC5IAjThLGsg4zGAGil9ABM_3QA2t0Z0bstB6E7EGPPfJx5OfVy9V3qx0q603IUcNsE6hLzrtONq0YiuriH6pyJpxt-ToaW-p_AWwFIIaUIhq1j3bW8aAYVceU1ZqyKimrY8pKFObFyuyXccbpD_E71iJoVkEqLb_FqG7DEn1Zz39cfwFCurh2</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Gautam, Ajay Prashad</creator><creator>Fernandes, Donald J.</creator><creator>Vidyasagar, Mamidipudi S.</creator><creator>Maiya, Arun G.</creator><creator>Nigudgi, Shantling</creator><general>Springer-Verlag</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20130501</creationdate><title>Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial</title><author>Gautam, Ajay Prashad ; Fernandes, Donald J. ; Vidyasagar, Mamidipudi S. ; Maiya, Arun G. ; Nigudgi, Shantling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-a55594c5f70c73cebed7cb752f9f4c487c6c1f898c12a6fbe6aa9478cab8e3bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Analysis</topic><topic>Analysis of Variance</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>Chemoradiotherapy - adverse effects</topic><topic>Chemoradiotherapy - methods</topic><topic>Cisplatin</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Head and neck cancer</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Lasers in surgery</topic><topic>Linear Models</topic><topic>Low-Level Light Therapy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nuclear radiation</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Opioids</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Parenteral Nutrition, Total - methods</topic><topic>Quality of Life</topic><topic>Rehabilitation Medicine</topic><topic>Severity of Illness Index</topic><topic>Stomatitis</topic><topic>Stomatitis - etiology</topic><topic>Stomatitis - pathology</topic><topic>Stomatitis - radiotherapy</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gautam, Ajay Prashad</creatorcontrib><creatorcontrib>Fernandes, Donald J.</creatorcontrib><creatorcontrib>Vidyasagar, Mamidipudi S.</creatorcontrib><creatorcontrib>Maiya, Arun G.</creatorcontrib><creatorcontrib>Nigudgi, Shantling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gautam, Ajay Prashad</au><au>Fernandes, Donald J.</au><au>Vidyasagar, Mamidipudi S.</au><au>Maiya, Arun G.</au><au>Nigudgi, Shantling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>21</volume><issue>5</issue><spage>1421</spage><epage>1428</epage><pages>1421-1428</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Chemoradiotherapy (CRT)-induced oral mucositis (OM) adversely affects a patient’s oral functions and quality of life (QOL). Low-level laser therapy (LLLT) showed some preventive and curative effects against clinically reported objective measures of OM in few trials including our recently published study. There is dearth of evidence regarding the effects of LLLT on patient’s subjective experience of OM and QOL. Hence, we did this study to evaluate the effects of LLLT on a patient’s reported measures of OM and QOL in head and neck cancer (HNC) patients receiving CRT.
Methods
This triple blinded study randomized 220 HNC patients scheduled for CRT (three weekly Cisplatin + RT = 66 Gray (2 Gy/session), five fractions/week for 6.5 weeks, total 33 fractions) into laser (110) and placebo (110) groups. The laser group received LLLT (Technomed Electronics Advanced Laser Therapy 1000, He–Ne,
λ
= 632.8 nm, power density = 24 mW/cm
2
, dosage = 3.0 J at each point, total dose/session = 36–40 J, spot size 1 cm
2
, irradiation time/point 125 s) before each radiation session, while the placebo group did not receive laser therapy. Methodology was similar to our recently published study (Gautam et al. Radiother Oncol 104:349–354,
2012
). In this part of our study, a blinded assessor collected subjective outcomes of the patient’s reported measures of OM using Oral Mucositis Weekly Questionnaire-Head and Neck (OMWQ-HN) and QOL using Functional Assessment of Cancer Treatment-Head and Neck (FACT-HN) Questionnaire. Data were analyzed using repeated measure ANOVA through general linear model. Statistical significance was kept at
p
< 0.05.
Results
Results analysis revealed that OMWQ-HN (
F
= 12.199,
df
= 6,1314,
p
< 0.001) and FACT-HN (
p
< 0.05) scores were significantly lower in LLLT than placebo group patients. Also, a significant reduction (
p
< 0.001) in incidence of severe OM, need for opioid analgesics, and total parenteral nutrition was observed.
Conclusions
LLLT was effective in improving the patient’s subjective experience of OM and QOL in HNC patients receiving CRT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23224689</pmid><doi>10.1007/s00520-012-1684-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Supportive care in cancer, 2013-05, Vol.21 (5), p.1421-1428 |
| issn | 0941-4355 1433-7339 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A336672549 |
| source | MEDLINE; Springer Online Journals Complete |
| subjects | Adult Aged Analgesics, Opioid - therapeutic use Analysis Analysis of Variance Cancer Cancer patients Care and treatment Chemoradiotherapy - adverse effects Chemoradiotherapy - methods Cisplatin Double-Blind Method Female Head and neck cancer Head and Neck Neoplasms - therapy Humans Lasers in surgery Linear Models Low-Level Light Therapy - methods Male Medicine Medicine & Public Health Middle Aged Nuclear radiation Nursing Nursing Research Oncology Opioids Original Article Pain Medicine Parenteral Nutrition, Total - methods Quality of Life Rehabilitation Medicine Severity of Illness Index Stomatitis Stomatitis - etiology Stomatitis - pathology Stomatitis - radiotherapy Surveys and Questionnaires Treatment Outcome |
| title | Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial |
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