Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In humans, PGRN haploinsufficiency is a major inherited cause of frontotemporal dementia (FTD), but how PGRN deficiency causes neurodegeneration is unknown. Here we show that loss of PGRN results in increased n...

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Veröffentlicht in:	The Journal of clinical investigation 2012-11, Vol.122 (11), p.3955
Hauptverfasser:	Martens, Lauren Herl, Zhang, Jiasheng, Barmada, Sami J, Zhou, Ping, Kamiya, Sherry, Sun, Binggui, Min, Sang-Won, Gan, Li, Finkbeiner, Steven, Huang, Eric J, Farese, Jr., Robert V
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Dementia Development and progression Gene expression Genetic aspects Neurons
Online-Zugang:	Volltext
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