Igf2 ligand dependency of [Pten.sup.+/-] developmental and tumour phenotypes in the mouse

The tumour suppressor PTEN is a key negative regulator of the PI3K-Akt pathway, and is frequently either reduced or lost in human tumours. Murine genetic studies have confirmed that reduction of Pten promotes tumourigenesis in multiple organs, and demonstrated dependency of tumour development on the...

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Veröffentlicht in:	Oncogene 2012-08, Vol.31 (31), p.3635
Hauptverfasser:	Church, D.N, Phillips, B.R, Stuckey, D.J, Barnes, D.J, Buffa, F.M, Manek, S, Clarke, K, Harris, A.L, Carter, E.J, Hassan, A.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis Genetic aspects Insulin-like growth factor 1 Physiological aspects Risk factors Tumor suppressor genes
Online-Zugang:	Volltext
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