Biological screening of Scrophularia nodosa extract and its fractions
Biological screening of Scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities. Crude extract and its fractions produced 50-100% phytotoxicity at...
Gespeichert in:
| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2012-04, Vol.25 (2), p.307 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | 307 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 25 |
| creator | Ahmad, Mansoor Muhammad, Noor Mehjabeen Jahan, Noor Alam, Syed Mahboob Ahmad, Manzoor Obaidullah |
| description | Biological screening of Scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities. Crude extract and its fractions produced 50-100% phytotoxicity at 1000μ/mL concentration whereas 25-77% phytotoxicity was observed at 10μ/mL concentration. The fractions exhibited significant antibacterial and antifungal effects. The non-toxic results of this plant were recorded in Brine Shrimps Bioassay method at all concentrations. Similarly no significant insecticidal activity was observed in crude extracts and fractions. Analgesic activity results of S. nodosa in mice were found highly significant in crude extract as compared to fractions. In writhing test crude extract at 500 mg/kg showed 65.6% highest inhibitory response in mice. |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_gale_infotracmisc_A292992891</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A292992891</galeid><sourcerecordid>A292992891</sourcerecordid><originalsourceid>FETCH-LOGICAL-g278t-5b6a5ebfa96af6af2f17455eb6244fc706edd26047d1e836b5ef5140047b34923</originalsourceid><addsrcrecordid>eNptkE9LxDAQxXNQ3HX1K0jAcyVJk7Q5rsv6BxY8qOCtpMmkRtqkJF3Qb2-X1YMgMzDMj_cew5ygJSWUFpLQtwU6z_mDEMmVUmdowRgXigu-RNtbH_vYeaN7nE0CCD50ODr8bFIc3_e9Tl7jEG3MGsPnlLSZsA4W-yljd9h8DPkCnTrdZ7j8mSv0erd92TwUu6f7x816V3SsqqdCtFILaJ1WUru5maMVFzORjHNnKiLBWiYJryyFupStACcoJzNoS65YuULXx9xO99D44OLhoMFn06yZYkqxWtFZdfOPai4LgzcxgPMz_2O4OhrGfTuAbcbkB52-mt83ld9Nz2Hk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Biological screening of Scrophularia nodosa extract and its fractions</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ahmad, Mansoor ; Muhammad, Noor ; Mehjabeen ; Jahan, Noor ; Alam, Syed Mahboob ; Ahmad, Manzoor ; Obaidullah</creator><creatorcontrib>Ahmad, Mansoor ; Muhammad, Noor ; Mehjabeen ; Jahan, Noor ; Alam, Syed Mahboob ; Ahmad, Manzoor ; Obaidullah</creatorcontrib><description>Biological screening of Scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities. Crude extract and its fractions produced 50-100% phytotoxicity at 1000μ/mL concentration whereas 25-77% phytotoxicity was observed at 10μ/mL concentration. The fractions exhibited significant antibacterial and antifungal effects. The non-toxic results of this plant were recorded in Brine Shrimps Bioassay method at all concentrations. Similarly no significant insecticidal activity was observed in crude extracts and fractions. Analgesic activity results of S. nodosa in mice were found highly significant in crude extract as compared to fractions. In writhing test crude extract at 500 mg/kg showed 65.6% highest inhibitory response in mice.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 22459454</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Analgesics ; Analgesics - pharmacology ; Animals ; Anti-Infective Agents - pharmacology ; Antibacterial agents ; Antioxidants ; Antioxidants - pharmacology ; Artemia ; Humans ; Plant Extracts - pharmacology ; Scrophularia</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2012-04, Vol.25 (2), p.307</ispartof><rights>COPYRIGHT 2012 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22459454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmad, Mansoor</creatorcontrib><creatorcontrib>Muhammad, Noor</creatorcontrib><creatorcontrib>Mehjabeen</creatorcontrib><creatorcontrib>Jahan, Noor</creatorcontrib><creatorcontrib>Alam, Syed Mahboob</creatorcontrib><creatorcontrib>Ahmad, Manzoor</creatorcontrib><creatorcontrib>Obaidullah</creatorcontrib><title>Biological screening of Scrophularia nodosa extract and its fractions</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Biological screening of Scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities. Crude extract and its fractions produced 50-100% phytotoxicity at 1000μ/mL concentration whereas 25-77% phytotoxicity was observed at 10μ/mL concentration. The fractions exhibited significant antibacterial and antifungal effects. The non-toxic results of this plant were recorded in Brine Shrimps Bioassay method at all concentrations. Similarly no significant insecticidal activity was observed in crude extracts and fractions. Analgesic activity results of S. nodosa in mice were found highly significant in crude extract as compared to fractions. In writhing test crude extract at 500 mg/kg showed 65.6% highest inhibitory response in mice.</description><subject>Analgesics</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Artemia</subject><subject>Humans</subject><subject>Plant Extracts - pharmacology</subject><subject>Scrophularia</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE9LxDAQxXNQ3HX1K0jAcyVJk7Q5rsv6BxY8qOCtpMmkRtqkJF3Qb2-X1YMgMzDMj_cew5ygJSWUFpLQtwU6z_mDEMmVUmdowRgXigu-RNtbH_vYeaN7nE0CCD50ODr8bFIc3_e9Tl7jEG3MGsPnlLSZsA4W-yljd9h8DPkCnTrdZ7j8mSv0erd92TwUu6f7x816V3SsqqdCtFILaJ1WUru5maMVFzORjHNnKiLBWiYJryyFupStACcoJzNoS65YuULXx9xO99D44OLhoMFn06yZYkqxWtFZdfOPai4LgzcxgPMz_2O4OhrGfTuAbcbkB52-mt83ld9Nz2Hk</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Ahmad, Mansoor</creator><creator>Muhammad, Noor</creator><creator>Mehjabeen</creator><creator>Jahan, Noor</creator><creator>Alam, Syed Mahboob</creator><creator>Ahmad, Manzoor</creator><creator>Obaidullah</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201204</creationdate><title>Biological screening of Scrophularia nodosa extract and its fractions</title><author>Ahmad, Mansoor ; Muhammad, Noor ; Mehjabeen ; Jahan, Noor ; Alam, Syed Mahboob ; Ahmad, Manzoor ; Obaidullah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-5b6a5ebfa96af6af2f17455eb6244fc706edd26047d1e836b5ef5140047b34923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analgesics</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Artemia</topic><topic>Humans</topic><topic>Plant Extracts - pharmacology</topic><topic>Scrophularia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmad, Mansoor</creatorcontrib><creatorcontrib>Muhammad, Noor</creatorcontrib><creatorcontrib>Mehjabeen</creatorcontrib><creatorcontrib>Jahan, Noor</creatorcontrib><creatorcontrib>Alam, Syed Mahboob</creatorcontrib><creatorcontrib>Ahmad, Manzoor</creatorcontrib><creatorcontrib>Obaidullah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmad, Mansoor</au><au>Muhammad, Noor</au><au>Mehjabeen</au><au>Jahan, Noor</au><au>Alam, Syed Mahboob</au><au>Ahmad, Manzoor</au><au>Obaidullah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological screening of Scrophularia nodosa extract and its fractions</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2012-04</date><risdate>2012</risdate><volume>25</volume><issue>2</issue><spage>307</spage><pages>307-</pages><issn>1011-601X</issn><abstract>Biological screening of Scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities. Crude extract and its fractions produced 50-100% phytotoxicity at 1000μ/mL concentration whereas 25-77% phytotoxicity was observed at 10μ/mL concentration. The fractions exhibited significant antibacterial and antifungal effects. The non-toxic results of this plant were recorded in Brine Shrimps Bioassay method at all concentrations. Similarly no significant insecticidal activity was observed in crude extracts and fractions. Analgesic activity results of S. nodosa in mice were found highly significant in crude extract as compared to fractions. In writhing test crude extract at 500 mg/kg showed 65.6% highest inhibitory response in mice.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>22459454</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1011-601X |
| ispartof | Pakistan journal of pharmaceutical sciences, 2012-04, Vol.25 (2), p.307 |
| issn | 1011-601X |
| language | eng |
| recordid | cdi_gale_infotracmisc_A292992891 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Analgesics Analgesics - pharmacology Animals Anti-Infective Agents - pharmacology Antibacterial agents Antioxidants Antioxidants - pharmacology Artemia Humans Plant Extracts - pharmacology Scrophularia |
| title | Biological screening of Scrophularia nodosa extract and its fractions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T15%3A20%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biological%20screening%20of%20Scrophularia%20nodosa%20extract%20and%20its%20fractions&rft.jtitle=Pakistan%20journal%20of%20pharmaceutical%20sciences&rft.au=Ahmad,%20Mansoor&rft.date=2012-04&rft.volume=25&rft.issue=2&rft.spage=307&rft.pages=307-&rft.issn=1011-601X&rft_id=info:doi/&rft_dat=%3Cgale_pubme%3EA292992891%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/22459454&rft_galeid=A292992891&rfr_iscdi=true |