A platelet-mediated system for shuttling blood-borne bacteria to [CD8α.sup.+] dendritic cells depends on glycoprotein GPIb and complement C3

The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic [CD8.sup.+] T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic [CD8α.sup.+] DCs. We report that L. monocytogenes rapidly...

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Veröffentlicht in:	Nature immunology 2011-12, Vol.12 (12), p.1194
Hauptverfasser:	Verschoor, Admar, Neuenhahn, Michael, Navarini, Alexander A, Graef, Patricia, Plaumann, Ann, Seidlmeier, Amelie, Nieswandt, Bernhard, Massberg, Steffen, Zinkernagel, Rolf M, Hengartner, Hans, Busch, Dirk H
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Blood platelets Dendritic cells Glycoproteins Health aspects Physiological aspects
Online-Zugang:	Volltext
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