Effect of Ipragliflozin (ASP1941), a Novel Selective Sodium-Dependent Glucose Co-Transporter 2 Inhibitor, on Urinary Glucose Excretion in Healthy Subjects

Background: Hyperglycaemia is associated with serious complications, significant morbidity and death. Despite the availability of a wide range of therapeutic options, many patients with diabetes mellitus fail to achieve or maintain recommended glycaemic goals. Ipragliflozin (ASP1941) is a novel, sel...

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Veröffentlicht in:	Clinical drug investigation 2011-12, Vol.31 (12), p.839-851
Hauptverfasser:	Veltkamp, Stephan A., Kadokura, Takeshi, Krauwinkel, Walter J. J., Smulders, Ronald A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Glucose - drug effects Blood Glucose - physiology Blood Pressure Determination Body Mass Index Complications and side effects Dextrose Diabetes Mellitus, Type 2 - drug therapy Diagnosis Dose-Response Relationship, Drug Double-Blind Method Electrocardiography - drug effects Female Glucose Glucose - metabolism Glucosides - adverse effects Glucosides - pharmacokinetics Glucosides - pharmacology Glucosides - therapeutic use Glycosuria - drug therapy Heart Rate - drug effects Humans Hyperglycemia Hyperglycemia - drug therapy Hyperglycemia - physiopathology Hypoglycemic Agents - adverse effects Hypoglycemic Agents - pharmacokinetics Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Internal Medicine Male Medicine Medicine & Public Health Middle Aged Original Research Article Pharmacology/Toxicology Pharmacotherapy Physiological aspects Placebos Sex Factors Sodium-Glucose Transporter 2 - antagonists & inhibitors Symporters - physiology Thiophenes - adverse effects Thiophenes - pharmacokinetics Thiophenes - pharmacology Thiophenes - therapeutic use Young Adult
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