Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which are often refractory to conventional therapies (1). Many MLL-fusion partners are members of the super elongation complex (SEC), a critical regulator of transcriptional...

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Veröffentlicht in:	Nature (London) 2011-10, Vol.478 (7370), p.529
Hauptverfasser:	Dawson, Mark A, Prinjha, Rab K, Dittmann, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C, Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M, Huthmacher, Carola, Gudgin, Emma, Lugo, Dave, Beinke, Soren, Chapman, Trevor D, Roberts, Emma J, Soden, Peter E, Auger, Kurt R, Mirguet, Olivier, Doehner, Konstanze, Delwel, Ruud, Burnett, Alan K, Jeffrey, Phillip, Drewes, Gerard, Lee, Kevin, Huntly, Brian J.P, Kouzarides, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Care and treatment Chromatin Health aspects Myelocytic leukemia Nonlymphoid leukemia Physiological aspects Risk factors Stem cells
Online-Zugang:	Volltext
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