Chagasic thymic atrophy does not affect negative selection but results in the export of activated [CD4.sup.+][CD8.sup.+] T cells in severe forms of human disease

Extrathymic [CD4.sup.+][CD8.sup.+] double-positive (DP) T cells are increased in some pathophysiological conditions, including infectious diseases. In the murine model of Chagas disease, it has been shown that the protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alteratio...

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Veröffentlicht in:	PLoS neglected tropical diseases 2011-08, Vol.5 (8)
Hauptverfasser:	Morrot, Alexandre, Terra-Granado, Eugenia, Perez, Ana Rosa, Silva-Barbosa, Suse Dayse, Milicevic, Novica M, Farias-de-Oliveira, Desio Aurelio, Berbert, Luiz Ricardo, De Meis, Juliana, Takiya, Christina Maeda, Beloscar, Juan, Wang, Xiaoping, Kont, Vivian, Peterson, Part, Bottasso, Oscar, Savino, Wilson
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Chagas' disease Diagnosis Gene expression Genetic aspects Physiological aspects Polymerase chain reaction T cells
Online-Zugang:	Volltext
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