Protective HIV-specific [CD8.sup.+] T cells evade [T.sub.reg] cell suppression

Specific human leukocyte antigens (HLAs), notably HLA-B*27 and HLA-B*57 allele groups, have long been associated with control of HIV-1. Although the majority of HIV-specific [CD8.sup.+] T cells lose proliferative capacity during chronic infection, T cells restricted by HLA-B*27 or HLA-B*57 allele gr...

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Veröffentlicht in:	Nature medicine 2011-08, Vol.17 (8), p.989
Hauptverfasser:	Elahi, Shokrollah, Dinges, Warren L, Lejarcegui, Nicholas, Laing, Kerry J, Collier, Ann C, Koelle, David M, McElrath, M. Juliana, Horton, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Development and progression Histocompatibility antigens HIV infection HLA histocompatibility antigens Physiological aspects T cells
Online-Zugang:	Volltext
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