HIV type 1-Mediated Downregulation of [HLA-B.sup.]57/[B.sup.]5801 proteins on elite suppressor [CD4.sup.+] T cells
Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of
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| Veröffentlicht in: | AIDS research and human retroviruses 2011-02, Vol.27 (2), p.183 |
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| container_issue | 2 |
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| container_title | AIDS research and human retroviruses |
| container_volume | 27 |
| creator | Sampah, Maame Efua S Ceccato, Christina M Blankson, Joel N |
| description | Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of |
| doi_str_mv | 10.1089/aid.2010.0144 |
| format | Article |
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While [HLA-B.sup.*]57 and B*5801 alleles are overrepresented in ES, many [HLA- B.sup.*]57/ [B.sup.*]5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of [HLA-B.sup.*]57 and [HLA-B.sup.*]5801 molecules on primary [CD4.sup.+] T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of [HLA-B.sup.*]57/B*5801 molecules do not distinguish ES from CP. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.</description><identifier>ISSN: 0889-2229</identifier><identifier>DOI: 10.1089/aid.2010.0144</identifier><language>eng</language><publisher>Mary Ann Liebert, Inc</publisher><subject>Development and progression ; Genetic aspects ; Health aspects ; Highly active antiretroviral therapy ; Histocompatibility antigens ; HIV (Viruses) ; HLA histocompatibility antigens</subject><ispartof>AIDS research and human retroviruses, 2011-02, Vol.27 (2), p.183</ispartof><rights>COPYRIGHT 2011 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Sampah, Maame Efua S</creatorcontrib><creatorcontrib>Ceccato, Christina M</creatorcontrib><creatorcontrib>Blankson, Joel N</creatorcontrib><title>HIV type 1-Mediated Downregulation of [HLA-B.sup.]57/[B.sup.]5801 proteins on elite suppressor [CD4.sup.+] T cells</title><title>AIDS research and human retroviruses</title><description>Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While [HLA-B.sup.*]57 and B*5801 alleles are overrepresented in ES, many [HLA- B.sup.*]57/ [B.sup.*]5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of [HLA-B.sup.*]57 and [HLA-B.sup.*]5801 molecules on primary [CD4.sup.+] T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of [HLA-B.sup.*]57/B*5801 molecules do not distinguish ES from CP. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.</description><subject>Development and progression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Highly active antiretroviral therapy</subject><subject>Histocompatibility antigens</subject><subject>HIV (Viruses)</subject><subject>HLA histocompatibility antigens</subject><issn>0889-2229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjM1LAzEQxXNQsFaP3gMeZbdJms9jbdUWKl6Kl1JKNpmUyHazbLaI_72LH-BB5jDvvfm9QeiGkpISbSY2-pKRwRHK-RkaEa1NwRgzF-gy5zdCiGFMjFC3XL3i_qMFTItn8NH24PEivTcdHE617WNqcAp4u1zPivsyn9pyJ9Rk-ys1objtUg-xyXhAoY494OHWdpBz6vB2vuBf7N0Ob7CDus5X6DzYOsP1zx6jzePDZr4s1i9Pq_lsXRykUgVzruKWsmA9V0YKIp0OwgrwmrCpE0J4LqUOUNnKaupA-IpZkAqomlLFpmN0-_32YGvYxyakvrPuGLPbzxg3UnPD1UCV_1DDeDhGlxoIccj_FD4BmQpnmA</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Sampah, Maame Efua S</creator><creator>Ceccato, Christina M</creator><creator>Blankson, Joel N</creator><general>Mary Ann Liebert, Inc</general><scope/></search><sort><creationdate>20110201</creationdate><title>HIV type 1-Mediated Downregulation of [HLA-B.sup.]57/[B.sup.]5801 proteins on elite suppressor [CD4.sup.+] T cells</title><author>Sampah, Maame Efua S ; Ceccato, Christina M ; Blankson, Joel N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g677-2ccb4a12fad4796506c8f5a5ed8023c555d4668febaba81ce5db2ae67e1731723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Development and progression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Highly active antiretroviral therapy</topic><topic>Histocompatibility antigens</topic><topic>HIV (Viruses)</topic><topic>HLA histocompatibility antigens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sampah, Maame Efua S</creatorcontrib><creatorcontrib>Ceccato, Christina M</creatorcontrib><creatorcontrib>Blankson, Joel N</creatorcontrib><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sampah, Maame Efua S</au><au>Ceccato, Christina M</au><au>Blankson, Joel N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV type 1-Mediated Downregulation of [HLA-B.sup.]57/[B.sup.]5801 proteins on elite suppressor [CD4.sup.+] T cells</atitle><jtitle>AIDS research and human retroviruses</jtitle><date>2011-02-01</date><risdate>2011</risdate><volume>27</volume><issue>2</issue><spage>183</spage><pages>183-</pages><issn>0889-2229</issn><abstract>Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While [HLA-B.sup.*]57 and B*5801 alleles are overrepresented in ES, many [HLA- B.sup.*]57/ [B.sup.*]5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of [HLA-B.sup.*]57 and [HLA-B.sup.*]5801 molecules on primary [CD4.sup.+] T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of [HLA-B.sup.*]57/B*5801 molecules do not distinguish ES from CP. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.</abstract><pub>Mary Ann Liebert, Inc</pub><doi>10.1089/aid.2010.0144</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 2011-02, Vol.27 (2), p.183 |
| issn | 0889-2229 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A249684947 |
| source | Mary Ann Liebert Online Subscription; Alma/SFX Local Collection |
| subjects | Development and progression Genetic aspects Health aspects Highly active antiretroviral therapy Histocompatibility antigens HIV (Viruses) HLA histocompatibility antigens |
| title | HIV type 1-Mediated Downregulation of [HLA-B.sup.]57/[B.sup.]5801 proteins on elite suppressor [CD4.sup.+] T cells |
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