Hypoxia induces intracellular [Ca.sup.2+] release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytes

Here we attempted to test a novel hypothesis that hypoxia may induce [Ca.sup.2+] release through reactive oxygen species (ROS)-mediated dissociation of FK506-binding protein 12.6 (FKBP12.6) from ryanodine receptors (RyRs) on the sarcoplasmic reticulum (SR) in pulmonary artery smooth muscle cells (PA...

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Veröffentlicht in:	Antioxidants & redox signaling 2011-01, Vol.14 (1), p.37
Hauptverfasser:	Liao, Bo, Zheng, Yun-Min, Yadav, Vishal R, Korde, Amit S, Wang, Yong-Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding proteins Calcium ions Complications and side effects Hypoxia Physiological aspects Proteolysis
Online-Zugang:	Volltext
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